Design, In-Vitro Evaluation of Diclofenac Sodium Fast Disintegrating Tablets by Using AegleMarmelos as a Natural Polymer
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 6
Abstract
Diclofenac sodium is a non-steroidal anti-inflammatory drug with analgesic and anti-inflammatory properties was selected as a model drug. The aim of the present work is to formulate a tablet which disintegrate, dissolve rapidly and give its rapid onset of action. The present study was to formulate and in-vitro evaluation of fast disintegrating tablets of Diclofenac sodium using fast disintegrating agents like Sodium Starch Glycolate, Crosspovidone and Natural polymer such as Aeglemarmelos (Bael Fruit) gum powder by direct compression technique in the concentration of 2%W/W, 4%W/W, 6%W/W & 8%W/W. Each formulation was evaluated for various pre and post compression parameters such as Flow property, Bulk density, Tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in-vitro dissolution. Among the 12 formulations, F12 formulation Diclofenac sodium with 8%w/w of Aeglemarmelos showed better disintegration time and enhance the dissolution rate. From the In-Vitro dissolution rate studies 99.97% release of drug within 25 minutes and the mechanism of drug release from the tablets was followed to be first order kinetics. FT-IR studies showed there was no interaction between the drug and polymers (or) excipients. Keywords:Diclofenac Sodium, NSAID, Sodium Starch Glycolate, Crosspovidone, Aeglemarmelos
Authors and Affiliations
P. SS. Prasanna Kumar, G. Vijaya Kumar, N. Srinivas, B. Devaki Devi, A. Bhavani, G. Mohini Priya, M. Anusha, S. R. V. S. K. Mahalaxmi
Keywords
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