Design of Pulsatile Tablets of Pantoprazole Sodium: Factorial Design Approach
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 3
Abstract
Abstract:The objective of the present study was to develop and optimize an oral pulsatile drug delivery system containing pantoprazole sodium to mimic the circadian rhythm of the peptic ulcer by releasing the drug with a distinct predetermined lag time. Six fast disintegration core tablets were prepared for preliminary trials using direct compression method. The tablets were evaluated for hardness, friability assay and dissolution study. The best formulation were selected for optimization to study the influence of Micro crystalline cellulose (MCC) and Sodium starch glycolate (SSG) using 32 full factorial design. The optimized formulations were selected for coating for pulsatile delivery. The results of the study indicate f3 formulation was suitable for scale up. Keywords:Pantoprazole Sodium, Factorial Design.
Authors and Affiliations
ReshmaFathima K
Keywords
Related Articles
- EP ID EP397423
- DOI -
- Views 89
- Downloads 0
Contemporary Review of Cardiac Amyloidosis
Abstract: Cardiac amyloidosis is underdiagnosed. Prevalence is increasing with age. Diagnosis can be elusive and challenging. High index of suspicion is required for recognition and prompt diagnosis. Cardiac amyloid diag...
Effectiveness of Functional Foods Containing Bitter Melon Peptide in Blood Glucose Controlling: A Preliminary Study
Abstract:Literature has confirmed the bitter melon is useful to reduce the levels of blood glucose. A functional food was developed by extracting critical ingredients from bitter melon with advanced techniques. The new i...
Evaluation/Comprehension of Prescription Writing in V.S General Hospital and Nagri Eye Hospital
Abstract: Improper comprehension of the prescription can lead to wrong drugs taken, misuse of the drug dosage, and ineffective drug action by not following the proper schedule, which was advised, or development of advers...
Silymarin as Herbal Medicine- A Review
Abstract:Silymarin, a flavonolignan contain phenolic and flavanoid component from Silybum marianum plant, is used for the strengthening against various liver conditions in both experimental models and clinical settings....
A Validated Reversed Phase HPLC Assay for the Determination of Gliclazide in Human Plasma
Abstract:A simple and precise reversed-phase high performance liquid chromatography (HPLC) method for the determination of gliclazide in human plasma was developed and validated. Using glipizide as an internal standard (...