DESIGN, PREPARATION, AND EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF BAMBUTEROL HYDROCHLORIDE
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objective: The self-micro-emulsifying drug delivery system (SMEDDS) of bambuterol hydrochloride was designed, prepared, and evaluated to overcome the problem of poor bioavailability.Methods: The designing of the formulation included the selection of oil phase, surfactant, and cosolvent/cosurfactant based on the saturated solubility studies. Psuedoternary phase diagram was constructed using aqueous titration method, to identify the self-emulsifying region. Different ratios of the selected surfactant and cosolvent/cosurfactant (Smix) were also studied and used to construct the ternary phase diagram. The prepared formulations of the SMEDDS were evaluated for drug content, morphology, globule size, robustness to dilution, emulsification time, optical clarity, and stability.Results: The formulation containing 10 mg bambuterol hydrochloride, triacetin (12.50% w/w), Tween 80 (43.75% w/w), and ethanol (43.75% w/w) was concluded to be optimized. The optimized SMEDDS not only showed optimum globule size, zeta potential, and drug content but was also found to be robust to dilution, formed emulsion spontaneously, and was stable. The optimized SMEDDS showed increased permeability of the drug across the intestinal membrane in ex vivo studies.Conclusion: The results suggest that bambuterol hydrochloride can be formulated as self-microemulsifying drug delivery system, and further, SMEDDS can be used to improve the oral bioavailability of bambuterol hydrochloride.
Authors and Affiliations
Sachin Saggar, Ashutosh Upadhayay, Manish Goswami
IMPACT OF HYDROALCOHOLIC CONCENTRATE OF HEMIDESMUS INDICUS AGAINST 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE PROMPTED PARKINSONISM IN MICE
Objective: The objective of this study was to evaluate the protective effect of Hemidesmus indicus against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model. Methods: A total of 18 male Swiss Albino...
ANALYSIS OF GUT FLORA FROM DAMP WOOD TERMITES (TRINERVITERMES SPP.) AND EXTRACTION, CHARACTERIZATION OF CELLULASE FROM THE ISOLATE
Objective: The objective of the study was to isolate, characterize, identify, and compare the potentials of cellulolytic strains isolated from the gut of damp wood termites (Trinervitermes species) collected from Chennai...
HEPATOPROTECTIVE ACTIVITY OF CORDIA OBLIQUA AGAINST PARACETAMOL-INDUCED LIVER TOXICITY ON WISTAR RATS
Objective: The ethanolic extract of Cordia obliqua (EECO) Willd. leaves was evaluated for hepatoprotective activity in Wistar rats by inducing hepatic damage with paracetamol. Methods: The leaves of C. obliqua were drie...
A REVIEW: ANTIMICROBIAL AGENTS BASED ON NITROGEN AND SULFUR CONTAINING HETEROCYCLES
At present, heterocyclic compounds and their derived forms have become strong reflection in medicinal research field because of their positive pharmacological and biological properties. Heterocycles are prosperous in nat...
PHYTOCHEMICAL ANALYSIS, HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY, AND EX VIVO ANTIOXIDANT POTENTIAL OF A HERBAL FRUIT EXTRACT
Objective: The objective of the present investigation was to determine the presence of various phytochemicals in an ethanolic herbal fruit extract (HFE) made up by a blend of fruits of Phyllanthus emblica (PE), Ananas co...