Design, Synthesis and Evaluation of the Biological Activities of Some New Carbohydrazide and Urea Derivatives
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2018, Vol 15, Issue 3
Abstract
Objectives: Urea and carbohydrazide derivatives are important compounds exhibiting cytotoxic activities. In this study, a series of new urea and carbohydrazide derivatives containing an pyridine ring were synthesized and evaluated for cytotoxic activity. Materials and Methods: The proposed structures of the synthesized compounds were confirmed using elemental analysis, IR, and 1H-NMR spectroscopic techniques. The cytotoxic potencies of synthesized compounds were determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) on BRCA mutant-carrying HCC1937 and Capan-1 cell lines, as well as on MCF7, HeLa, and MRC5 cells. Results: 3a, 3b, 3c and 3d showed cytotoxic activity against all cancer cell lines. Conclusion: Our data indicate that compounds 3a-d are more selective to cancer cells compared with nontumoral fibroblasts; however, these compounds are not more potent on HR defective cells with BRCA mutants.
Authors and Affiliations
Fatih TOK, Recep İLHAN, Selin GÜNAL, Petek BALLAR-KIRMIZIBAYRAK, Bedia KOÇYİĞİT-KAYMAKÇIOĞLU
Keywords
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- EP ID EP421237
- DOI 10.4274/tjps.64935
- Views 122
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