DESIGN, SYNTHESIS, CHARACTERIZATION OF SOME NEW SUBSTITUTED CHALCONES AND STUDIES THEIR ANTIMICROBIAL ACTIVITIES
Journal Title: International Journal of Engineering Sciences & Research Technology - Year 30, Vol 5, Issue 6
Abstract
Eight designed chalcones, named [1(p-benzenesulphonamidophenyl)-3-p-chloro-2-propene-1-one][2], [1(pbenzenesulphonamidophenyl)- 3-p-nitro-2-propene-1-one][3], [1(4-Ureido)phenyl-3-p-chlorophenyl-2-propene- 1-one][5], [1(4-Ureido)phenyl-3-p-nitroophenyl-2-propene-1-one][6], [1(4(p-N-methylaminophenyl)azophenyl- 3-p-chlorophenyl-2-propene-1-one][8], [1(4(p-N-methylaminophenyl)azophenyl-3-p-nitroophenyl-2-propene-1- one][9], [1(p-aminophenyl)-3-p-chlorophenyl-2-propene-1-one][10] and [1(p-aminophenyl)-3-p-nitrophenyl-2- propene-1-one][11], were synthesised by condensation of synthesised p-acetylphenylbenzene- sulphonamide, pacetylphenylurea and p-acetyl-p'-(N-methylamino)azobenzene, with p-chlorobenzaldehyde and pnitrobenzaldehyde in basic media respectively. All synthesised compounds are characterized by its melting points, FTIR, 1H NMR, 13C NMR and Mass spectral analysis.All synthesised compounds are examined their antimicrobial activities against Gram-Ve bactria (Serratiamarcescens, Pseudmonas aeroginosa) and Gram+Ve bacterial (Stphylococcus aureus, Streptococcus pyogenes), and Candida albicans fungi. Result showed good to moderate inhibition effect against some bacteria and fungi, in comparison with some pharmaceutical antibiotic and antifungal treatments like Cephalexin, Amoxicillin, Tetracycline, Lincomycine, Nystatine and Fluconazole respectively.
Authors and Affiliations
Zakaria H. Aiube
Keywords
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- EP ID EP117923
- DOI 10.5281/zenodo.55982
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