Designing and Evaluation of Dual Release Bi-Layer of Aceclofenac Optimized By SSG and Combination Of HPMC K 4M and PVP- K30
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
The aim of the present investigation to development and evaluation of bi-layer drug delivery system of aceclofenac to produce rapid and continuous action throughout the treatment to increase the patient compliance. Drugs with short half life cannot maintain the plasma drug concentration at the therapeutic levels for a longer period of time. So as to decrease the dosing frequency and increase the patient compliance sustained release bi-layer tablets were designed. Developed immediate release instant and rapid action and sustain release maintain the plasma drug concentration level. The physicochemical properties of the optimized bi-layered was investigated. Sodium starch glycolate and combination of HPMC K4M and PVP- K30 was incorporated bi-layer formulation to achieve the desired drug release profile. The formulation containing HPMC K4M and PVPK30 was selected as the optimized batch since it showed the best drug release profile within 6 hours as compared to the other formulations. The optimized batch was also analyzed for its morphological, physiochemical and drug release properties. Batches with combination of HPMC and PVK30 were evaluated for the % drug release. This work indicates the possible advantage in designing of sustain release medication for the long term treatment.
Authors and Affiliations
Popin Kumar*, Tulsi Bish, Poornima Belwal
Keywords
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