DESIGNING OF COLON SPECIFIC MATRIX TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The main aim of the study was to develop colon specific sustained release matrix tablets of diethyl carbamazine citrate (DEC), an anthelmintic for improving patient compliance, delivered to colon for its effective actions. The colon targeted matrix tablet was prepared by wet granulation technique using different percentage of guar gum as matrix carrier and coated with Eudragit L 100.Seven batches of matrix tablets were prepared with varying percentage of guar gum and hydroxyl propyl methyl cellulose (HPMC).The dissolution study of DEC matrix tablet in simulated colonic fluid (phosphate buffer pH 6.8) was 96.78% at the end of 24hr study. The best result of studies showed that colon targeted matrix tablet containing 48% guar gum was most to provide targeting of DEC for local action in the colon. Short term stability studies (at 40±2ºC/75±5% RH for 3 months) on the best formulation indicated that there no significant changes in drug content. IR spectroscopic study indicated that there are no drug excipient interactions.
Authors and Affiliations
Chinmaya Sahoo , Satyanarayana Kokkula, Jagadabi Rao , Hemanta Kumar, Tanmaya Sahoo , Binayak Das
Keywords
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