DETECTION OF ACQUIRED MULTIDRUG-RESISTANT TUBERCULOSIS AND EXTENSIVELY DRUGRESISTANT TUBERCULOSIS IN AND AROUND KOLKATA IN RECENT PAST
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 90
Abstract
BACKGROUND Nowadays tuberculosis is a serious global problem. There is an estimated 8-10 million new cases of tuberculosis worldwide with 2- 3 million deaths occurring in each year. In many parts of the world, including India, tuberculosis is the leading cause of death from any one infectious agent. It has been further estimated that tuberculosis is directly responsible for an estimated 7% of all deaths and 26% of all preventable deaths throughout the world. Aim- To find the antibiotic susceptibility patterns of isolates of Mycobacterium tuberculosis from different specimens in and around Kolkata after introduction of RNTCP. Objective- To study the antitubercular drug-resistant pattern of the M. tuberculosis isolates in urban population. MATERIALS AND METHODS A prospective observational study was carried out in the laboratory of the institution. All data regarding patient characteristics, disease characteristics, along with previous treatment and the antibiotic sensitivity pattern of the isolates were prospectively recorded from April 2002 to June 2008. During this period, 461 of 1207 culture-positive cases were tested. Data were further analysed. RESULTS Out of 461 isolates of M. tuberculosis, there were 232 cases of multidrug-resistant TB (MDR-TB), the percentage being 54.4%. Total number of extensively drug-resistant TB (XDR-TB) cases were 9, the percentage being 1.9%. There was a steady increase in frequency of MDR – isolates with ongoing years. CONCLUSION The study demonstrates the antitubercular drug-resistant pattern of the M. tuberculosis isolates in mostly urban population who were treated with various combination of first-line antitubercular drugs including the drug regimen prescribed by RNTCP. It will help us in our efforts of controlling drug resistance by modifying treatment regimen and other lacunae in the delivery system.
Authors and Affiliations
Battacharya C. P
Keywords
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- EP ID EP278236
- DOI 10.14260/jemds/2017/1373
- Views 65
- Downloads 0
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