Detection of Extended Spectrum Beta-Lactamases in Pseudomonas aeruginosa Isolates in a Tertiary Care Hospital
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background: Extended spectrum ß-lactamases (ESBLs) represent a major group of lactamases responsible for resistance, mostly produced by gram-negative bacteria, to newer generations of ß-lactam drugs currently being identified in large numbers worldwide. The aim of the present study was to detect the extendedspectrum β-lactamase (ESBL) production among Pseudomonas aeruginosa isolates from various samples. Materials and Methods: A total of 100 Pseudomonas aeruginosa isolates from various samples in a tertiary care hospital from January 2011 to December 2011 were included in the study. Kirby-Bauer’s disc diffusion method was employed to detect the antibiotic susceptibility pattern of the isolates. The isolates were tested for ESBL production using double-disc synergy test (DDST) using ceftazidime alone and combined ceftazidimeclavulanic acid discs. Result: Out of the 100 Pseudomonas aeruginosa isolates studied, 45 (45%) were ESBL producers .Out of the ESBL producing isolates, 44 (98%) were resistant to third generation cephalosporins, 28 (62%) to Ciprofloxacin ,34(76 %) to Gentamicin, 28(62%) to Amikacin respectively. 45(100%) of isolates were susceptible to Imipenem. Conclusion: This study emphasizes on the need for global control of antimicrobial resistance; and to create awareness among the clinicians and general population thereby reducing the mortality and morbidity associated with multi-drug resistant pathogens
Authors and Affiliations
P R Lyra
Keywords
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