Detection of high molecular weight IgG fibronectin complexes in various types of Acute Myeloid Leukemia - A study in third world country
Journal Title: International Archives of Integrated Medicine - Year 2015, Vol 2, Issue 3
Abstract
To detect presence of high molecular weight com¬plexes of IgG and fibronectin, plasma of patients with Acute Myeloid Leukemia was examined by polyethylene glycol (PEG) precipitation, analytical ultracentrifugation, and immunoaffinity chromatography. Ultracen¬trifugation identified abnormal circulating high molecular weight IgG in all patients. This was precipitated by PEG and was shown by exclusion chromatography to contain IgG in a high molecular weight form. Exam¬ination of plasma by immunoaffinity chromatography supported evidence for complex formation between IgG and fibronectin and further showed that abnormal high molecular weight IgG complexes are a prominent feature of Acute Myeloid Leukemia and implicate IgG fibronectin complex formation.
Authors and Affiliations
Debkumar Ray, Debashis Roy Burman, Indranil Dhar, Soumik Ghosh, Debabrata Nandy
Keywords
Related Articles
- EP ID EP529115
- DOI -
- Views 106
- Downloads 0
Study of pre-operative and post-operative variables for incisional hernia repair by open and laparoscopic technique
Background: Incisional hernia is protrusion of part or whole of abdominal viscus through the weakness in layers of anterior wall in the scar of previous operation. The major predisposing factors being post operative woun...
Multiple myeloma in 33 years old male patient - A case report
Multiple myeloma is a condition of malignant plasma cell proliferation derived from a single B-cell lineage. These cells produce monoclonal immunoglobulins, most commonly either immunoglobulin G (IgG) or immunoglobulin A...
Giant peptic ulcer perforation: Omentopexy versus omental plugging - A study
Giant peptic ulcer perforation is a life threatening surgical emergency with high mortality rate. This study compares two different surgical techniques Omentopexy and Omental plugging for the treatment of giant peptic pe...
A study of cardiovascular involvement in Hypothyroidism
Background: Cardiac abnormalities associated with hypothyroidism attracted great deal of investigational effort. There are only few studies done in our country to asses CVS parameters in hypothyroid patients. Hypothyroid...
A study on endoscopic abnormality in drug induced UGI bleeding
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin are among the most frequently prescribed drugs worldwide and are available ‘Over-The-Counter’ (OTC) also. Though reasonably safe in most cases...