Detection of Isoniazid Induced Hepatitis after 12 Weeks and Its Management
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Hepatotoxicity is a common complication of anti-tuberculosis therapy ranging in severity fromasymptomatic elevation of hepatic transaminases to hepatic failure necessitating liver transplantation. Thistoxicity is caused by most anti-tuberculosis drugs but appears to represent an idiosyncratic response and isusually seen in the first six weeks of starting anti-tuberculosis treatment (ATT) mainly due toIsoniazid(INH) and Rifampicin. The hepatotoxicity seen after twelve weeks is majorly due to Pyrazinamide.However sometimes Isoniazid can be an offending agent after 12 weeks.
Authors and Affiliations
Dr. Jitesh Dhingra
Keywords
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