Detection of Macrolide-Lincosamide-Streptogramin B Resistance in Staphylococci Isolated from Ear Discharge of Patients of Chronic Suppurative Otitis Media in a Tertiary Care Hospital
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 9, Issue 1
Abstract
Staphylococci act as major aerobic pathogens in the causation of chronic suppurative otitis media (CSOM). Clindamycin is one of the alternative agents used to treat CSOM and accurate identification of clindamycin resistance is important to prevent therapeutic failure. Inducible clindamycin resistance cannot be detected by standard susceptibility tests. This study aimed to detect macrolide-lincosamide-streptogramin B (MLSB) resistance in staphylococcal isolates causing CSOM in order to assist clinicians in treatment of CSOM by thesegroup of antibiotics. MLSB resistance in the present study was detected in 59 staphylococcal isolates (41 S. aureus and 18 CONS) isolated by standard procedure from ear discharge in CSOM. D-test was performed on these isolates to detect MLSB resistance. Inducible clindamycin was detected in 5% Methicillinsusceptible staphylococcus aureus (MSSA), 0% Methicillinresistant staphylococcus aureus (MRSA) and 5.5% CoagulasenegativeStaphylococci (CONS). Constitutive resistance (8.4%) was found more common than inducible clindamycin resistance (5%) in the present study. Detection of inducible clindamycin resistance can help in using clindamycin safely and effectively in patients with true clindamycin susceptible isolates and thus helps to avoid treatment failure while high prevalence of constitutive resistance makes D-test essential when clindamycin is an option for therapy of staphylococci in CSOM.
Authors and Affiliations
Chetana I , Vanita A. Kulkarni
Keywords
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