Detection of Porphyromonas gingivalis DNA in the synovial fluid of rheumatoid arthritis patients by real-time PCR
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 11
Abstract
Microbial infections are believed to play an important role in the initiation and perpetuation of rheumatoid arthritis. This study aimed to investigate the relationship between the presence of Porphyromonas gingivalis DNA in the synovial fluid and rheumatoid arthritis. The synovial fluid samples were collected from 22 patients with rheumatoid arthritis and 20 patients with not suffering from rheumatism, overall 42 patients were investigated. The presence of P. gingivalis DNA was evaluated by the real-time PCR method. There was a significant relationship between rheumatoid arthritis and non-rheumatoid arthritis with the DNA number (Pv< 0.05). P. gingivalis DNA were detected in 3 of 20 (13.6%) rheumatoid arthritis patients, but there was no significant relationship between P. gingivalis DNA and rheumatoid arthritis (Pv> 0.05). DNA of periodontal pathogens can be found in the synovial fluid of rheumatoid arthritis patients. It shows oral bacteria may play a role in the pathogenesis of rheumatoid arthritis.
Authors and Affiliations
Reza Ghotaslou| Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Mohammadreza Nakhjovani| Internal Medicine Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Javid Sadeghi| Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Hamed Ebrahimzadeh Leylabadlo| Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran, Behrouz Daghighazar| Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Solmaz Mirmahdavi| Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Microbiology Department, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran, Corresponding Email: soli_mahdavi@yahoo.com
Keywords
Related Articles
- EP ID EP12201
- DOI -
- Views 272
- Downloads 15
Preconcentration and analysis of cannabinoid compounds (THC-9, CBN, CBD) in urine samples by IL-ISFME/D-µ-SPE/HPLC-DAD
In this work we applied a recently developed ionic liquid assisted in-situ solvent formation microextraction coupled with magnetic nano-particle based dispersive micro-solid phase extraction following by HPLC diode arra...
Relationship between nurse's general health and their personal occupational traits in Al-Zahra Hospital of Isfahan, 2015
Health state is one of the most important factors in their life. Individuals may be subject to threatening factors in different ways. Nurses are one main group of community whose health may be threatened due to their oc...
Prevalence of and risk factors for falls and disability among elderly individuals in a Turkish population (Trabzon Province)
Falls are a significant problem in the elderly. The aim of the study was to investigate the prevalence of falls and the risk factors for falls and disability in an elderly population. In this study with a descriptive an...
A CROSS SECTIONAL STUDY OF THE MORBIDITY PATTERN AMONG THE ELDERLY PEOPLE : SOUTH INDIA
Background: In 1950, just 8% of the world population was aged 60 years or over, by 2005 that proportion had risen to 10% and it is expected to be more than double over the next 45 years, reaching 22% by 2050. Evaluatio...
Investigating the influence of local antiseptics on the level of urinary tract infection (UTI) among patients undergoing transrectalbiopsy of prostate
Transrectal ultrasound guided biopsy of the prostate is the most common modality used to diagnose prostate cancer. The main complication of this modality is prostatitis. The purpose of this study is to determine the eff...