Detection of Sutterella in the Stool of Egyptian Children with Autism Spectrum Disorders
Journal Title: Microbiology Research Journal International - Year 2017, Vol 22, Issue 2
Abstract
Background: Autism spectrum disorder (ASD) is a multifaceted group of neurodevelopmental disorders. Gastrointestinal problems are commonly reported in children with autism and may correlate with autism severity. A recent study reported that Sutterella species were frequently found in individuals with autism that was not found in controls. Aim: The aim of the present study was to study the role of Sutterella species in Egyptian children with Autism Spectrum Disorders (ASDs). Methods: Thirty children diagnosed with ASDs according to DMS-V criteria aged between 2.5-8 years old together with a cross matching control group of 30 healthy neurotypical children were included in the present study. Gastrointestinal symptoms were assessed with a modified six-item GI Severity Index (6-GSI) questionnaire. Stool specimens were taken for detection of Sutterella by the Conventional PCR using primers that amplify a 260-bp region spanning the variable regions from V6 to V8 of the 16S rRNA gene. Results: Sutterella species was detected in 24 cases out of 30 ASD patients (80%), and in 11 (36.7%) out of the control cases. There was no significant correlation between the presence of Sutterella and the severity of ASD or GSI. Conclusion: These results indicate that Sutterella species may have a role in ASD.
Authors and Affiliations
Nancy Younis Omar, Shwikar M. Abdelsalam Ahmed, Hanan Azouz, Sarah Magdy Abdelhamid, Naglaa Moustafa Abdelaziz
Keywords
Related Articles
- EP ID EP316121
- DOI 10.9734/MRJI/2017/37988
- Views 66
- Downloads 0
Relationship between Gingivitis and Autism in Children: A Matched Case-control Study
Autism is a neurodevelopmental disorder diagnosed in early childhood. Studies have shown that autistic children have poorer gingival health and hence chances of higher incidence of gingivitis may occur in autistic than n...
Poultry Environment as a Reservoir of Antimicrobial Resistant Bacteria – A Nigerian Story
Aims: This study set out to help define the role of the poultry environment as a reservoir of drug resistant bacteria in Nigeria. Introduction: The poultry environment has been acclaimed as a potential source of antimicr...
The Seroprevalence of Human Papilloma Virus (HPV) Types 6,11,16 and 18 among Women Attending Cervical Screening (Pap Smear) Service in Abakaliki, Southeastern Nigeria
The seroprevalence of the causative agent of cervical cancer: Human Papilloma Virus (HPV) types in any region is essential for the effective prevention and control of cervical cancer in that region, since there are over...
Bacteriological and Pathological Studies of Mammary Glands Affections in Camels (Camelus dromedarius) at Tumbool Abattoir, Sudan
Aims of the Study: To isolate and identify the bacteria associated with mastitis and study the pathology of udder tissue. Study Design: Out of 353 culled she-camels (from Tumbool abattoir), 105 (29, 7%) sections of udder...
Antibacterial Potential of Different Parts of Aerva lanata (L.) Against Some Selected Clinical Isolates from Urinary Tract Infections
Aims: To investigate the antibacterial activity of different parts of Aerva lanata against Staphylococcus saprophyticus, Streptococcus agalactiae, Acinetobacter baumannii, Xanthomonus citri, Klebsiella pneumoniae and Pro...