Detection Of Wuchereria Bancrofti And Onchocerca Volvulus Antigens Using Igg4 Antibodies Among Residents Of Bakassi Local Government Area Of Cross River State, Nigeria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Onchocerciasis and lymphatic filariasis have remained a public health problem, despite several efforts over the years to eliminate them. The prevalence of human lymphatic filariasis and onchocerciasis was determined amongst 400 residents of Ekpri-Ikang,Ikang and Ebot-20 community of Bakassi Local Government Area, Cross River State, Nigeria. The subjects were 140 males and 260 females within the age range of 18-50 years and above who were involved in various occupations including farming, fishingand trading. Onchocerciasis and lymphatic filariasis infections were diagnosed by the detection of Wb123 and Ov16 antigens using IgG4 antibodies in the SD biolinefilariasis and Onchocerciasis kit. Knott”s concentration technique and Skin snip test were also performed using blood and skin biopsies respectively. . A total of 64(16%) and 20(5%) of the study subjects harboured antigen of W. bancrofti and O. volvulus respectively. In Ikang community ,the prevalence rate of W . bancroftiwas 12(5.7%). In terms of gender 28(20%) male and 36(13.9%) female subjects were positive for W. bancrofti whereas 8(5,7%)male 12(4,6%)female subjects were positive for onchocerca vulvolus respectively. For both infections although the male subjects were more infected than the female counterparts, the difference was not statiscally significant (X2 = 0.96 and 0.93; P>0.05). The highest infection rate of 16(14.8%) and 12(13.6%) for W. bancrofti was observed in persons within the age range of 26-33 years and 34-41 years respectively. The highest infection of 12(11.1%) for O. volvulus was observed in persons within the age range of 26-33 years. However, there was no statistically significant differencein infection rate with to age-groups. Also there was no statistically significant difference in the prevalence of infection with respect to the people occupations (X2=0.96 and and 0.97; P>0.05) .However farmers fishermen were more infected i.e 28(23.3%) and 20(35.7%), and 8(6.7%) and 8(14.3%) for W. bancrofti and O. volvulus respectively. The study has revealed the presence of Wuchereria bancrofti and Onchocerca volvulus antigens and circulating microfilariae in the blood of residents in Bakassi Local Government Area of Cross River state,Nigeria. It is hereby recommended that efforts should be intensified towards a complete eradication of these diseases in the study area. This can be achieved through massive distribution of ivermectin and albendazole to the local dwellers as well as health education on the mode of transmission of these diseases.
Authors and Affiliations
Mbah , M, akpan S. S, Ogba. O. M& Agiande . J
Keywords
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- EP ID EP582686
- DOI 10.9790/0853-1711106470
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