DETERMINATION OF ANDROGRAPHOLIDE IN ANDROGRAPHIS PANICULATA EXTRACTS WITH AND WITHOUT HUMAN SERUM BY HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
Andrographis paniculata (Acanthaceae)commonly known as Kalmegh is used both in Ayurvedic and Unani system of medicines for a number of ailments. Kalmegh contains bitter principles – Andrographolide, 14-deoxy-11, 12- didehydroandrographolide, neoandrographolide, 14-deoxy-11, oxyandrographolide, 14-deoxy-andrographolide, and flavonoids. HPTLC analysis indicates that the maximum amount of andrographolide was present in extracts of Andrographis paniculata prepared by refluxation. Amount of Andrographolide in all extracts with and without serum along with the % recovery is compared and the variation was found to be < 15 %. The HPTLC method developed for estimation of andrographolide is simple, sensitive and accurate.
Authors and Affiliations
Mohan Manvitha
Keywords
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