DETERMINATION OF APOE GENE EXPRESSION IN MULTIPLE SCLEROSIS PATIENTS
Journal Title: Kocatepe Medical Journal - Year 2021, Vol 1, Issue 22
Abstract
OBJECTIVE: Apolipoprotein E (ApoE) is a glycoprotein that functions as a ligand in receptor-mediated endocytosis of lipoprotein particles. There are studies showing the association of APOE with neurogenerative diseases such as Alzheimer's disease and multiple sclerosis (MS). The aim of this study was to investigate whether there is a relationship between APOE gene expression and MS. MATERIAL AND METHODS: To determine the effect of APOE gene expression on multiple sclerosis patients, we have included 35 MS patients and 20 healthy subjects into the study. The level of APOE mRNA expression was determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). For statistical analysis, t-test, chi-square test, Kruskal-Wallis test and Mann-Whitney U test were performed using SPSS package program and p <0.05 was considered as statistically significant. RESULTS: As a result, the comparison of ApoE gene expression in multiple sclerosis patients and healthy people using real-time PCR technique did not show any statistical significance between the groups (p=0.95). CONCLUSIONS: Our study does not support that ApoE gene expression may be related to MS. Further studies are needed to determine the role of ApoE in Multiple Sclerosis disease.
Authors and Affiliations
Suat ÇAKINA, Selma YÜCEL, Cemre Çağan POLAT
Keywords
Related Articles
- EP ID EP697479
- DOI https://doi.org/10.18229/kocatepetip.633385
- Views 85
- Downloads 0
INVESTIGATION OF THE RELATIONSHIP OF COMPUTED TOMOGRAPHY HISTOGRAM ANALYSIS WITH SURVIVAL TIME AND LOCAL CONTROL TIME IN HEAD AND NECK SQUAMOUS CELL CARCINOMA TREATED WITH CHEMORADIOTHERAPY
OBJECTIVE: This study aimed to evaluate the association between computed tomography (CT) histogram analysis and overall survival and local control in head and neck squamous cell carcinoma (HNSCC) treated with chemoradiot...
COMPARING OF LIFE QUALITY AND BODY-MASS INDEX OF HEALTHCARE UNDERGRADUATE STUDENTS
OBJECTIVE: In this study, it was aimed to compare the life quality of students who are studying in different health fields on the same campus and to correlate them with their Body Mass Index. MATERIAL AND METHODS: The s...
DEEP NECK INFECTIONS IN CHILDREN; DATA FROM A TERTIARY HOSPITAL
OBJECTIVE: Deep neck infections (DNIs) are the infections developing in potential spaces between the layers of deep servical fascia. Clinical course may progress from early manifestations such as cellulite, myositis to s...
EFFECTIVENESS OF FRACTURE-END REGENERATION OR EXTRACORPOREAL SHOCK WAVE THERAPY IN DELAY OF TIBIAL UNION: EXPERIMENTAL STUDY
OBJECTIVE: The purpose of this present study was to compare the results of fracture regeneration or Extracorporeal Shock Wave Therapy (ESWT) added to the fracture dynamization procedure in the rat tibia delayed union mod...
BODY SURFACE AREA AND USAGE AREAS
Body surface area is an anthropometric parameter used in many areas like drug dose adjustment, burn treatment, and determination of fluid requirement, as well as to calculate the basal metabolic rate. It is critical for...