Determination of Correction Factor for the Calculation of 24 Hour I-131 Thyroid Uptake by Gamma Camera with HEGP Collimator
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: The aim of this study was to determine the correction factor for the calculation of 24 hour I-131 thyroid uptake using a Gamma Camera with HEGP Collimator in patients with thyroid disease. This study we initially performed on phantom and in second phase it was performed on randomly chosen 25 patients to ascertain the appropriate value of correction factor for the calculation of gamma camera based thyroid uptake. In these patients had benign thyroid disorders and most of who had been referred for Thyroid evaluation before radioiodine-131 treatment. For this study Neck Phantom (Capintec Inc., Ramsey, USA), made up of Lucite, Gamma Camera (Discovery NMCT/670, GE make, USA), Thyroid uptake probe (Captus 3000, Capintec Inc, USA), Pipettes (Tarson made) and Dose Calibrator (Captus 3000, Capintec Inc, USA) were used and fine tune the others relevant parameter. The desired amount of radioiodine-131 Sodium Iodide solution activity i.e. 1.85MBq (50 μCi) was prepared with the help of pipetting technique and was administered to the patient with adequate flushing of the vial to ensure maximum oral administration of the dose. Radioiodine-131 uptake was usually measured at 25 cm distance from the face of the crystal to the anterior neck or phantom and also 24 hours thyroid uptake was calculated by using a probe-based method and a camera-based method with a high-energy parallel-hole (HEGP) collimator. Gamma camera based thyroid uptake was calculated by two method syringe method and decay correction method for later method first we need to derived appropriate correction factor and then applies it. Radioiodine thyroid uptake value was measured by syringe method with gamma camera had a significant difference when we compare with the value we got by thyroid uptake probe. Therefore we need to derive an appropriate correction factor and by applying a study specific correction factor in gamma camera uptake value, we can equate the uptake value of probe method and gamma camera method. When we apply a correction factor 0.87 derived for gamma camera based thyroid uptake measurement we found that the uptake values with the help of gamma camera was very close to the uptake value obtains by thyroid probe system. Radioiodine-131 thyroid uptake measured by proper ROIs and corrected by applying correction factor 0.87 the gamma camera with High energy collimator (HEGP) method can yield accurate and consistent result and thus the camera based method is a good substitute for the thyroid probe based method.
Authors and Affiliations
Dhananjay Kumar Singh, Devesh C. Bhatt, Satyawati Deswal
Keywords
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