Determination of effectiveness of berberine, a characteristic phytochemical of Berberis species, against human proteome using in-silico analysis
Journal Title: Journal of Biodiversity and Environmental Sciences (JBES) - Year 2014, Vol 4, Issue 5
Abstract
Berberis spp. are important representative plants of Family Berberidaceae. Berberis pseudumbellata subsp. gilgitica and Berberis brandisiana are found in Central Karakorum National Park (CKNP) and rest of GilgitBaltistan province of Pakistan (formerly Northern mountainous areas of Pakistan). Berberis pseudumbellata subsp. gilgitica is an endemic species and has become critically endangered. They are major source of Berberine which is an essential therapeutic phytochemical agent with anticancer, anti-diabetic, anti-AIDS, anti-jaundice, anti-cholera, anti-diarrhea, anti-leprosy and anti-inflammation effects. Studies illustrate inhibitory effect on oncogene-protein expression and therefore considered as an alternative, safer and effective medicine for chemotherapy. Besides being a multi-potent natural agent to combat Alzheimer’s disease, its effectiveness against cardiovascular, hypertension, musculoskeletal and ocular ailments cannot be ignored. Present in-silico analysis investigated cancer related Berberine-protein, Berberine lead protein-protein metabolic pathways, interactions and level of effect and role in cellular activities of human metabolic process. Moreover, study also attempts to reflect on action mechanism which is not clear so far. Using FDR= <0.001 as filter molecular function, cellular compartment and Biological processes are shortlisted to identify effect of Berberine on human body. Moreover, analysis is also carried out using FI reactome plugging and pathway predicted to be effected by effectors proteins with FDR= <0.001 score are shortlisted. Study reveals that Berberine has strong positive effect and correlation between Berberine and various carcinomic proteins as exhibited through molecular docking filtered on the basis of Z’-score <-0.05. Study contributes into understanding of Berberine as an alternate potential non-toxic anticancer drug.
Authors and Affiliations
Tika Khan, Imtiaz Ahmed Khan, Abdul Rehman, Zohra Bibi
Keywords
Related Articles
- EP ID EP37672
- DOI -
- Views 148
- Downloads 0
An Efficient Approach of Focused Time Delay Neural Network in Drought Forecasting in Central Iran
An exact prediction and modeling of drought is essential for watersheds management. The main contribution of this research is in the design, performance and comparison of drought forecasting models using Focused Time Del...
Quantitative gene expression analysis of NHX1 and HvPIP2;1 in barley (HordeumvulgareL.) under salinity stress
Plant sodium transporters activity and plasma membrane intrinsic proteins are the most important salt tolerance mechanisms in plants. In the present study, the expression pattern of genes encoding Na+/H+ exchanger (NHX1...
Functional response of Trichogramma brassicae Bezdenko to Anagasta kuehniella (Zeller) and Phthorimaea operculella (Zeller) eggs
The parasitoid Trichogramma brassicae Bezdenko is used for inundative releases in biological control programs against lepidopteran pests in agro-ecosystems. Study on the functional response of natural enemies is one of t...
The role of phenological stages of hammada salicornica on grazing management and sustainable utilization of rangeland forage
Hammada salicornica is a key range species in arid regions. In this study, phenological stages of Hammada salicornica were investigated at two desert vegetative regions of AbBarik Bam (Kerman province) and Tabas (Yazd...
Effect of thiamine on blood glucose changes after maximal aerobic exercise in non-athlete university students male
This study is conducted with the aim of investigating the effect of vitamin B1 (Thiamine) on blood glucose changes. We observed that when the subjects received 300 mg thiamin /day, there was a lowering of blood glucose...