Determination of Glutathione Reductase Activity Changes Exposed to Some 2-Aminothiazole Derivatives
Journal Title: Cumhuriyet Science journal - Year 2019, Vol 40, Issue 1
Abstract
In this work, effects of concentrations ranging from 0 to 500 mg/L of some 2-aminothiazole derivatives such as 4,4’-(disulfanediylbis(methylene))bis(thiazol-2-amine) dihyrochloride (DMTA) and 2-amino-4-(chloromethyl)thiazole hydrochloride (ACT) on glutathione reductase from baker's yeast (Saccharomyces cerevisiae) (GR) were investigated. With exposure of 25, 50, 100, 250 and 500 mg/L concentrations, % GR activity changes were calculated as -5.29 ; -3.85 ; -2.40 ; -6.73 and -10.58 in DMTA applications, while these changes were calculated as +0.98 ; 0.00 ; -0.49 ; -2.45 and 0.00 in ACT applications, respectively. This work indicated that there was a slight decrease in GR activity with the increase of DMTA concentrations and there was no significant change in GR activity with the increase of ACT concentrations. But according to control activities, no statitistical changes were observed in GR activities with exposure of these 2-aminothiazole derivatives (p > 0.05, n=3).
Authors and Affiliations
Hasan KARADAĞ, Emine EROĞLU, Cumhur KIRILMIŞ
Keywords
Related Articles
- EP ID EP488263
- DOI 10.17776/csj.504690
- Views 51
- Downloads 0
Investigation on Gamma Radiation Shielding Behaviour of CdO–WO3–TeO2 Glasses from 0.015 to 10 MeV
In the present study, the gamma radiation shielding properties of glasses in CdO–WO3–TeO2 ternary systems have been calculated using WinXCom program. The mass attenuation coefficient (, half value layer (HVL), effective...
A New Spherical Catalyst For Hydrogen Evolution Reaction
CuFeZn composite catalysts have been prepared on the graphite electrode by electrochemical deposition as electrocatalytic materials for hydrogen evolution reaction (HER). The etching process was applied on catalysts in c...
Some Results On Quaternion 3-Space
In this paper, the set J′=H(Q₄,Jγ) of 4 by 4 matrices, with entries in a quaternion F-algebra Q, that are symmetric with respect to the canonical involution Jγ is studied. J′ is also the special Jordan matrix algebra and...
Experimental Investigation of Free Convection from Foam Heat Sinks in an Inclined Rectangular Channel
In this present study, free convection from an in-line 5x1 array of aluminum foam heat sinks which were placed on the bottom wall of the inclined rectangular channel was investigated. Aluminum foam heat sinks were made o...
Determination of Buried Archaeological Structures By Archeogeophysical Methods (Olba, Mersin, Turkey)
Today, there are many research areas where interdisciplinary studies are quite common. One of these is the joint research carried out by geological engineers, geophysical engineers and archeologists. The use of geophysic...