Determination of malondialdehyde, Uric Acid, Bilirubin And Total Antioxidant Status, in Children Under 5 Years Suffering From Malaria in Osogbo, Nigeria
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background: Children are prone to malaria infection. Peroxidation of membranes lipids, hemolysis and oxidative stress due to invasion of erythrocytes by malaria parasites could worsen the disease and increase mortality. Aim: Evaluation of Malondialdehyde (MDA), Total Antioxidant Status (TAS), uric acid and bilirubin in children suffering from malaria. Materials and Method: Thirty malaria patients (age 1-5 years) were divided into two groups based on density of parasitaemia: Group1 = thirteen children scored as (+) and group2 = seventeen children scored as (++). Thirty apparently healthy children (age 1-5 years, parasitaemia score= -) served as control. Serum from groups 1, 2 and control were used to determine levels of uric acid, TAS, MDA and bilirubin by standard spectrophotometric methods. Results: Results showed that mean uric acid in group1 (5.28 ± 0.19) and group2 (5.96 ± 0.25) as well as MDA levels (group1=6.36 ± 0.17; group2= 7.97 ± 0.44) were higher than means of corresponding control (uric acid=3.69 ± 0.10, MDA=1.02 ± 0.06) respectively. Lower TAS level (group1= 1.16 ± 0.02 group2=0.92 ± 0.06) than control (1.44 ± 0.01) was observed. Conclusion:Malarialeads to increased peroxidation, haemolysis and oxidative stress possibly resulting in depletion of the body’s antioxidant defenses and decreased TAS. Children, generally not enthusiastic about intake of fruits and vegetables may benefit from antioxidant supplementation during malaria bouts.
Authors and Affiliations
M. J. Olisekodiaka, A. J. Onuegbu, C. Igbeneghu, N. Nwagbo, U. K. Amah, J. E. Okwara
Keywords
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- EP ID EP595458
- DOI 10.9790/0853-1604086569.
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