Abstract

Aim: In this study, the sensitivity of minocycline, polymyxin B, colistin and phosphomycin to carbapenem-resistant multiresistant Acinetobacter baumannii ( A. baumannii) strains (resistant to three or more antibiotic groups) isolated from patients in Ankara Training and Research Hospital It was aimed. Material and Method: Eighty nosocomial A. baumannii strains with a carbapenem-resistant multidrug resistance phenotype were included in the study. Sensitivities of minocycline, polymyxin B and phosphomycin were determined by disc diffusion test and colistin susceptibility test by disk diffusion and E-test methods. Results: Eighty (100%) polymyxin B, 75 (93,75%) minocycline sensitive and 4 (5%) medium susceptible to 80 carbapenem resistant A. baumannii strains were evaluated by disc diffusion method. 75 (93.5%) were sensitive to colistin, 5 (6.25%) were moderately sensitive to colistin and 2 (2.5%) were sensitive to phosphomycin. By e-test, all 80 strains (100%) were detected as susceptible to colistin. The MIC range for colistin was 0.125-1.5 μg / ml, the MIC 50 value was 025 μg / ml (the MIC range was found to be 0.5 μg / ml). Conclusion: Polymyxin B and minocycline could be used in therapy because phosphomycin B and susceptibility rates were high in empirical treatment of carbamazepine resistant multispecific A. baumannii strains in our hospital. Phosphomycin could not be used in treatment because of high resistance rate

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