Determination of Reference Range for B12 and Folate Levels According to Laboratory Data in an Adult Population
Journal Title: Bagcilar Medical Bulletin - Year 2020, Vol 5, Issue 4
Abstract
Objective: The aim of this study was to establish reference intervals (RIs) according to laboratory data in a population and to assess the vitamin B12 (B12) and folate status related to RIs for all age and gender groups. Method: The data were retrospectively provided from the laboratory information system of Balıkesir State Hospital. The selected patient population comprised 36.284 individuals (70.2% female, 29.8% male) between the age of 18 and 80 years. These participants were separated into six age-based subgroups (18-30, 31-40, 41-50, 51-60, 61-70 and 71-80 years). B12 and folate concentrations were measured by the ARCHITECT i2000sr (Abbott Diagnostics, Abbott Park, IL, USA) autoanalyzer. Extreme values were excluded by using IBM SPSS. The 95% RIs were obtained by the non-parametric method. Results: The results of 20.850 patients for B12 and of 14.183 for folate were evaluated. The mean ages of patients for B12 and folate were 48.9±16.3 years and 49.7±16.6 years, respectively. Mean ± standard deviation concentrations of B12 and folate were 220±77 pmol/L and 13.9±6.5 nmol/L, respectively. 95% RIs were calculated as 97-397 pmol/L for vitamin B12 and 5.17-30.9 pmol/L for folate in the entire population. There are statistically significant differences between women and men for B12 and folate. In addition, there is a significant difference between age groups for folate but not for B12 concentrations. Conclusion: In this study, differences between the reference ranges recommended by the manufacturer and the reference ranges of our own population were found. Our results indicate that determining the true reference range is vital.
Authors and Affiliations
Medine Alpdemir, Mehmet Fatih Alpdemir
Keywords
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- EP ID EP691488
- DOI 10.4274/BMB.galenos.2020.07.031
- Views 191
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