DETERMINATION OF THE INSILICO ANTIBACTERIAL ACTIVITY OF AMLODIPINE
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
The dihydropyridine amlodipine was proven to be very effective bactericidal. Here we attempted to propose a possible mechanism of action of amlodipine as antibacterial by insilico docking at the catalytic domain (CA) of various bacterial histidine kinases of six bacterial strains and by comparing the binding energies and types of interactions between amlodipine and the different enzymes. Results revealed that amlodipine could be antibacterial by inhibiting the phosphorylation at the catalytic domain of bacterial histidine kinases.
Authors and Affiliations
Sanaa Mohamed Eltayeb Ahmed
Keywords
Related Articles
- EP ID EP619198
- DOI -
- Views 124
- Downloads 0
FREQUENCY OF ANEMIA IN KING KHALID GENERAL HOSPITAL IN ALMAJMA'AH (INDOOR AND OUTDOOR PATIENTS)
Background and purpose: Anaemia is a disease prevalent worldwide, effects all age groups, and almost all countries are affected heavily, according to WHO 24.8% (1.62 billion people) of the population is effected worldwid...
LEVEL OF WRONG AWARENESS ABOUT OSTEOPOROSIS IN ALMADINA AL-MONWRA IN KSA
Background: globally, osteoporosis is a health problem leading to an increased risk of fractures and other serious complications. However, awareness and perceptions of susceptibility and belief in the seriousness of a di...
PRESCRIBING TRENDS OF ANTI-ULCERANT DRUGS BY GENERIC NAMES IN DHAKA CITY OF BANGLADESH
This study aimed to identify the prescribing preference of anti-ulcerant drugs among the physicians and dentists of Dhaka City, Bangladesh by generic names. A questionnaire-based field survey was conducted on the physici...
INTRAUTERINE INSEMINATION (IUI) PREGNANCY RATE AFTER HYSTEROSALPINGOGRAPHY (HSG)
Objective: To see the pregnancy rate through IUI after doing HSG. Methods: 40 women with unexplained infertility stimulated for ovulation induction then 20 of them was undergo IUI (GP A) and the other 20 we do for them H...
AN UPDATE ON DIGITAL DENTISTRY
To date, there has been various softwares used in the field of dentistry as a whole, be it in case history, imaging and in clinical practice management. This article classifies the different types of dental softwares and...