DETERMINATION OF THE INSILICO ANTIBACTERIAL ACTIVITY OF AMLODIPINE
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
The dihydropyridine amlodipine was proven to be very effective bactericidal. Here we attempted to propose a possible mechanism of action of amlodipine as antibacterial by insilico docking at the catalytic domain (CA) of various bacterial histidine kinases of six bacterial strains and by comparing the binding energies and types of interactions between amlodipine and the different enzymes. Results revealed that amlodipine could be antibacterial by inhibiting the phosphorylation at the catalytic domain of bacterial histidine kinases.
Authors and Affiliations
Sanaa Mohamed Eltayeb Ahmed
Keywords
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