Determination uncertainty of aluminum residues in human albumin using top-down evaluation
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 5
Abstract
Objective To evaluate the determination uncertainty of aluminum residues in human albumin by inductively coupled plasma mass spectrometry (ICP-MS). Methods The aluminum residues in human albumin was determined by ICP-MS, and the top-down method was applied to assess the reasons of uncertainty and calculate the uncertainty. Results The relative standard uncertainty of the aluminum content in human albumin at the three quality control levels was 0.54 ng/mL, 1.68 ng/mL and 4.54 ng/mL, respectively, which met the requirements of the guidelines for bioanalytical methods in the Chinese Pharmacopoeia(2020). Conclusion The top-down method is simple and quick to assess the uncertainty of aluminum residues in human albumin, and is suitable for the uncertainty assessment of analytical methods in biological laboratories.
Authors and Affiliations
Meiling ZHENG, Zhiming LI, Danfeng LI
Keywords
Related Articles
- EP ID EP738547
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.05.011
- Views 6
- Downloads 0
Secondary herpes zoster wound cured by allogeneic platelet-rich plasma: a case report
Objective To investigate the feasibility of allogeneic platelet-rich plasma (PRP) for the treatment of herpes zoster wounds secondary to systemic lupus erythematosus (SLE), especially large ulcer wounds. Methods The trea...
Expert consensus on RhD blood group testing strategies in blood transfusion compatibility testing laboratories
RhD antigen is the most immunogenic antigens in the Rh blood group system and can cause hemolytic transfusion reactions (HTRs) and severe hemolytic disease of the fetus and newborn (HDFN). RhD-negative red blood cell (RB...
HBV serological characteristics between NRR samples and OBI samples of from blood donors in Hefei
Objective To analyze the correlation of HBV serological characteristics between non-reproducible reactivity (NRR) samples and occult hepatitis B virus infection (OBI) samples for blood screening. Methods A total of 144 s...
Effects of two oral calcium agents on the changes of Ca2+ and PTH in first-time and regular blood donors
Objective To investigate the effects of oral calcium gluconate and calcium lactate granules on the changes of serum calcium(Ca2+ ) and parathyroid hormone (PTH) in first-time and regular apheresis platelet donors. Method...
Perioperative allogenic blood transfusion for single disease in patients undergoing spinal deformity correction surgery:a longitudinal observational study
Objective To analyze the profile of perioperative allogenic blood transfusion for single disease in patients who underwent spinal deformity correction surgery and risk factors of the blood transfusion, in order to provid...