DETERMINING THE IMPACT OF ADMINISTRATION OF JATROPA GOSSIPIIFOLIA ON THE CYTOARCHITECTURE OF THE TESTES OF TREATED MALE WISTAR RATS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 4
Abstract
This study was aimed at investigating the impact of administration of Jatropa gossipiifolia on the cytoarchitecture of the testes of treated male Wistar rats. 1.3kg of the leaves of Jatropa gossipiifolia were washed and air dry and macerated in 50% ethanol. Forty male adult albino Wistar rats were used, the animals were randormly divided into 4 groups which were administered with 5ml of distilled water (control), 86.58mg/kg (group 2), 175.21mg/kg (group 3) and 250.81mg/kg of the extract respectively for 28days. After the last dose schedule, the animals were sacrificed and the testes removed for histopathological examination. Results from this study reveals degeneration of connective tissue, mild interstitial cell edema and mild to scanty germinal epithelia population in animals administered with 86.561mg/kg of jatropa gossipiifolia. Similarly, degeneration of connective tissue, interstitial cell necrosis and severe to scanty germinal epithelia population was observed in animals administered with 175.21mg/kg of Jatropa gossipiifolia. Connective tissue degeneration, interstitial cell infiltration and necrosis, intraparenchymal hemorrhage and severe germinal epithelial erosion was evident in animals administered with 250.81mg/kg of Jatropa gossipiifolia. It can therefore be concluded that Jatropa gossipiifolia has a devastating effect on the cytoarchitecture as well as the reproductive parameters of the testes.
Authors and Affiliations
Gabriel D. Edem
Keywords
Related Articles
- EP ID EP651948
- DOI -
- Views 187
- Downloads 0
PREVALENCE OF CRYPTOSPORIDIOSIS AMONG DIARRHOEIC PATIENT’S ATTENDING TO KOSTI TEACHING HOSPITAL, WHITE NILE STATE, SUDAN
Cryptosporidiosis is the disease caused by Cryptosporidium parvum, is of great concern because of associated economic losses and the public health significance in humans. The aim of this study was to determine the preval...
COMPARATIVE STUDY OF ENDOPHYTIC FUNGAL METABOLITE ISOLATED FROM BLACK TURMERIC (CURCUMA CAESIA ROXB.) IN ROS ASSOCIATED CAENORHABDITIS ELEGANS MODEL SYSTEM
Free radicals containing oxygen, known as reactive oxygen species (ROS) is one of the important factors of aging-associated diseases. Excess production of ROS and insufficient cellular antioxidant reverse compromise cell...
CONCEPT OF “DEHIK PRAKRUTI” (PERSONALITY) AND ITS IMPORTANCE IN HOMEOSTASIS-A REVIEW
Ayurvedic concepts regarding way of diagnosis, mode of treatment, classification of disease and determination of prognosis of disease etc. all the issues differ from modern science by one point of view i.e. Prakruti. Pra...
COMPARISON OF FEV1 REGARDLESS OF RATIO (FRR) WITH FORCED EXPIRATORY RATIO (FER) IN COPD; TO INCORPORATE PRESERVED RATIO IMPAIRED SPIROMETRY (PRISM)
Background: Traditionally spirometric criteria of post-bronchodilator FEV1/FVC is used to define Chronic Obstructive Pulmonary Disease(COPD). This has been termed as forced expiratory ratio(FER)(1). It is however, well o...
CLINICAL CASE: RENAL CARBUNCLE IN A PREGNANT WOMEN
Despite the advances in the treatment of inflammatory urinary system diseases during pregnancy, one of the possible complications still include renal carbuncle, which often leads to kidney loss, and, in severe cases, - t...