Determining the role of mother race in neonatal outcome of trisomies 21, 18 and 13 using cell free DNA analysis
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 12
Abstract
To determine the role of mother race in neonatal outcome of trisomies 21, 18 and 13 using cell free DNA (cf-DNA) analysis. All women administered for a sonographic imaging at their 10-22 weeks’ gestation which were qualified for cf-DNA testing were suggested for increasing aneuploidy risk, between March 1, 2015 to March 30 , 2016. The cf-DNA analysis was conducted after women received genetic counseling in a specialty laboratory. The results were validated by amniocentesis. A total of 1992 women were screened using cf-DNA analysis. The participants were 1631 Non Arabs (Fars, Kurd, and Lor) and 361 Arabs. The fetus risk for trisomy 21 in the Arab women of Arab race was two as much as Non Arab race, but trisomies 18 and 13 in women of Non Arab race were more than Arab race. The role of mother race (such as Arab and Non Arab) in neonatal outcome is very important.
Authors and Affiliations
Najmie Saadati| Associated professor of Obstetrics and Gynaecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran and Fellowship perinatology ward , Maternal-fetal medicine research center, Shiraz University of Medical Sciences, Shiraz, Iran, Razieh Mohammad Jaafari| Associated professor of Obstetrics and Gynaecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Maternal-fetal Medicine Research Center , Ahvaz, Iran Corresponding email:Rmj417072@gmail.com, Mojgan Barati| Associated professor of Obstetrics and Gynaecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Maternal-fetal Medicine Research Center , Ahvaz, Iran, Maria Cheraghi| Associated professor of Social Determinant of Health, Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Gholamreza Shariati| Assistant professor of Medical Genetic , School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran and director of Narges Pathobiology and Genetic lab, Maedeh Sohani| Resident of Obstetrics and Gynaecology, School of Medicine, Fertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Keywords
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