Development and Advanced Validation of an Optimized Method for the Quantitation of Aβ42 in Human Cerebrospinal Fluid
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 3
Abstract
The online version of this article (doi:10.1208/s12248-012-9360-7) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Valerie C. Cullen, Ross A. Fredenburg, Cindy Evans, Phyllis R. Conliffe, Michael E. Solomon
Keywords
Related Articles
- EP ID EP681237
- DOI 10.1208/s12248-012-9360-7
- Views 70
- Downloads 0
Effect of Device Design on the In Vitro Performance and Comparability for Capsule-Based Dry Powder Inhalers
The online version of this article (doi:10.1208/s12248-012-9379-9) contains supplementary material, which is available to authorized users.
Differential Metabolism of Organic Nitrates by Aldehyde Dehydrogenase 1a1 and 2: Substrate Selectivity, Enzyme Inactivation, and Active Cysteine Sites
Organic nitrate vasodilators (ORN) exert their pharmacologic effects through the metabolic release of nitric oxide (NO). Mitochondrial aldehyde dehydrogenase (ALDH2) is the principal enzyme responsible for NO liberation...
Synthesis and Pharmacological Characterization of a Novel Sigma Receptor Ligand with Improved Metabolic Stability and Antagonistic Effects Against Methamphetamine
Methamphetamine interacts with sigma receptors at physiologically relevant concentrations suggesting a potential site for pharmacologic intervention. In the present study, a previous sigma receptor ligand, CM156, was opt...
Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention
Phenethyl isothiocyanate (PEITC)—a naturally occurring isothiocyanate in cruciferous vegetables—has been extensively studied as a chemopreventive agent in several preclinical species and in humans. Pharma...
Enhancement of MHC-I Antigen Presentation via Architectural Control of pH-Responsive, Endosomolytic Polymer Nanoparticles
The online version of this article (doi:10.1208/s12248-014-9697-1) contains supplementary material, which is available to authorized users.