DEVELOPMENT AND ANTIMICROBIAL POTENTIAL OF SOAP BASED ON AQUEOUS EXTRACT OF LEAVES OF MORINDA MORINDOIDES (MORINDA, RUBIACEAE) AGAINST CUTANEOUS PATHOGENS.
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Different extracts of leaves of Morinda morindoides (Baker) Milne-Redh (Rubiaceae) showed interesting in vitro antimicrobial activities against pathogenics involved in cutaneous infections. The purpose of this investigations was to formulated soap based on aqueous extract of leaves of the plant as antimicrobial agent and tested it activity against 2 bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) and 4 fungi (Candida albicans, Candida tropicalis, Trichophyton rubrum and Trichophyton mentagrophytes). The method of study was to developed soap (Soap S1) by incorporation of aqueous extract of M. morindoides as antimicrobial agent in formula of basic soap (Soap S0). Antimicrobial parameters (MIC and IC50) of 2 soaps (S0 and S1) against the above microorganisms strains were determined by agar both dilution and plate methods. All strains tested were inhibited by both types of soaps with values of MIC ranging between 62.50 – 31.25 mg/mL and 125.00 – 62.50 mg/mL respectively for soap S1 and soap S0. C. albicans was the least strain whereas T. mentagrophytes was most sensitive in the presence of 2 soaps. In comparison with control soap (S0), these results showed that aqueous extract of M. morindoides gave to soap S1 an effective antimicrobial power on tested microorganisms. This investigation is a part of valorization of previous work of our research team on extracts of M. morindoides. Thus this finding is a real hope in development of products to effectively prevent or fight microbial cutaneous infections.
Authors and Affiliations
TOURE Abdoulaye
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