Development and Biopharmaceutical Characterization of BCS Class II Drug – Naproxen by Two Way Complexation Solid Dispersion Technique

Journal Title: International Journal of Bio-Pharma Research - Year 2019, Vol 8, Issue 4

Abstract

The objective of this study was to increase the solubility and bioavailability of Naproxen (NP) by fabricating ternary solid dispersion (tSDs) with water soluble polymer PEG 6000 and crospovidone. tSDs were prepared and optimized by 32 full factorial design with PEG 6000 level (X1) and CP level (X2) as independent variables and percent drug release (D80, (Y)) as dependent variable. The optimized tSDs were evaluated for their physicochemical properties which confirmed the formation of tSDs (DSC), SEM suggested smooth surface and compact structures. PXRD revels that drug was still present in crystalline form and was not molecularly dispersed in the complex especially in non-homogeneous part of the tSDs. The optimized tSDs revels that Dissolution rate (Y) was significantly affected by independent variable PEG 6000 (X1) while CP (X2) was insignificant. The transparent characteristics of tSDs was observed as a result of lowered Tg temperature gives higher dissolution rate up to 97.70 % for optimized formulation (F9). The pharmacokinetic study in Han Wistar rats showed that the tSDs had the greatest effect on oral bioavailability of NP in vivo test showed that NP (tSDs) presented significantly larger AUC0-t, which was 1.09 folds more than that of marketed formulation. Cmax of NP (tSDs) also increased from 120 µg/ml to 146 µg/ml compared to that of marketed formulations and generated shortened Tmax of (1.0 ± 0.416) h, compared to marketed dosage form (2.0 ± 0.456) h.

Authors and Affiliations

Milind Dharmraj Kamble, Zahid Zaheer, Santosh Mokale, Rana Zainuddin

Keywords

Related Articles

A Comprehensive qualitative phytochemical estimation of Euphorbia neriifolia Linn.

Euphorbia neriifolia Linn. is a restorative plant of Euphorbiaceae family, utilized as Indian conventional medication in bronchitis, tumors, leucoderma, heaps, irritation, spleen broadening, weakness, ulcers, and fever....

Isolation and screening of glucose oxidase producing Aspergillus oryzae strain MF13 from marine source

Glucose Oxidase (GOx) received numerous applications in the food industry and clinical fields. Marine fungi extensively recognized for their ability to harvest enzyme source. In this study, we have made an effort to coll...

Morpho-Anatomical studies of Atalantia racemosa Wight ex Hook., an important medicinal plant of Chittoor Dt. of Andhra Pradesh, India.

Atalantia racemosa Wight ex Hook., belongs to the family Rutaceae and is widely used as ethnomedicine in and around chittoor district of Andhra Pradesh for various ailments. In this paper we attempted for authenticity in...

Performance of Solar cell fabricated using TiO2: rGO on glass and Si substrates prepared by Thermal Evaporation Technique

TiO2: rGO doped material is deposited on glass and Si substrates. These hetero nanostructures have multiple applications in photovoltaic because of their charge transport properties. In this study, we prepared tetragonal...

Development and Biopharmaceutical Characterization of BCS Class II Drug – Naproxen by Two Way Complexation Solid Dispersion Technique

The objective of this study was to increase the solubility and bioavailability of Naproxen (NP) by fabricating ternary solid dispersion (tSDs) with water soluble polymer PEG 6000 and crospovidone. tSDs were prepared and...

Download PDF file
  • EP ID EP534984
  • DOI 10.21746/ijbpr.2019.8.4.1
  • Views 159
  • Downloads 0

How To Cite

Milind Dharmraj Kamble, Zahid Zaheer, Santosh Mokale, Rana Zainuddin (2019). Development and Biopharmaceutical Characterization of BCS Class II Drug – Naproxen by Two Way Complexation Solid Dispersion Technique. International Journal of Bio-Pharma Research, 8(4), 2523-2530. https://europub.co.uk/articles/-A-534984