DEVELOPMENT AND CHARACTERIZATION OF FENOFIBRATE TABLET BY COMPARING TWO DIFFERENT SOLUBILITY AND DISSOLUTION ENHANCEMENT METHODS
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2018, Vol 6, Issue 5
Abstract
Fenofibrate is a drug included in BCS class II category, generally used to reduce cholesterol level in patient having a risk of cardiovascular disease. The main aim of this research was to ameliorate solubility and dissolution profile of Fenofibrate with comparison between two different methods i.e. Solid dispersion and liquisolid technique. In liquisolid system, a dry freely flowing and compressiblepowder mixture was obtained which absorb drug solution or suspension in non-volatile solvent. While in case of solid dispersion drug was dispersed with suitable hydrophillic carrier with or without volatile solvent to get powder material. Two formulationsof Fenofibrate solid dispersion were prepared by solvent evaporation method using β-CD as a hydrophillic carrier with ratios 1:1 and 1:3. In case of liquisolid technique, two liquisolid compacts were prepared with ‘R’ value 20:1 and 40:1 using Avicel PH 102 as a carrier and Aerosil 200 as a coating material. All the formulations were characterized by FTIR, DSC and solubility studies. Precompression studies of all the batches were done by determining angle of repose (25.100-35.020), bulk density (0.51-0.56 g/ml), tapped density (0.60-0.66 g/ml), carr’s index (15.61-19.03%) and hausner’s ratio (1.13-1.25). Post compression evaluation was done by checking hardness (4-5 kg/cm2), thickness (3.56-4.01mm), friability (0.54-0.75%), disintegration time (3.50-5.56min), drug content (80.34-95.05%) and in-vitrodrug release (81.55-92.93%). Out of all the four batches SD2 batch that was prepared by solid dispersionshowed an excellent result by releasing drug at 96.91 %.
Authors and Affiliations
Beerpal Kaur, J. S Dua, D. N Prasad
Keywords
Related Articles
- EP ID EP506962
- DOI 10.22270/ajprd.v6i5.423
- Views 144
- Downloads 0
ANTI FERTILITY ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF TRILLIUM GOVANIANUM IN ETHINYL ESTRADIOL INDUCED ANTI FERTILITY MODEL IN RATS
Lack of fertility is in fertility were as anti-fertility is to reduce fertility. Fertility is burning issue of global as well as national public issue which are concerning the fast growth of the country. Increase rate of...
RP-HPLC Method Development and Validation for Estimation of Acebrophylline
Acebrophylline is ananti-inflammatory and airway mucus regulator. It had ambroxol and theophylline-7-acetic acid, the former facilitates the biosynthesis of pulmonary surfactant which raises blood levels of a...
DESIGN AND CHARACTERISATION OF TRANSDERMAL FILM OF GLICLAZIDE FOR THE TYPE-II DIABETES
Oral drug delivery system has various drawbacks like poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood levelspikes (both high and low), leading to a need for...
PREPARATION AND EVALUATION OF BETA SITOSTEROL NANOGEL: A CARRIER DESIGN FOR TARGETED DRUG DELIVERY SYSTEM
Transdermal drug delivery system is promising but challenging system available for local as well as systemic effect of the drug. The prolonged residence of drug formulation in the skin is important for transdermal drug d...
FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF ANTI-ALLERGIC DRUG
The aim of present work was the development of fast dissolving oral film of Loratadine to overcome the limitations of currentroutes of administration, to provide immediate action and increase the patient compliance. To i...