DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES FOR BUCCAL DELIVERY OF PREGABALIN
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 3
Abstract
Pregabalin is a structural analogue of the inhibitory neurotransmitter γ-amino butyric acid (GABA) having short half-life (5-6 hrs) and is used in the management of epilepsy. The aim of this study was to prepare a buccal patch containing Pregabalin by the means of solvent casting method. Six formulations were prepared using different ratio of polymers including HPMC K4M, Eudragit RL, and PVP K30. Since buccal mucosa is relatively permeable with rich blood supply and acts as an excellent site for the absorption of drugs so, it is an attractive alternate to other conventional methods of systemic drug administration. Franz diffusion cell with commercially available dialysis membrane was used for the in-vitro diffusion study of buccal patches for duration of 12 hrs. Kinetics and mechanism of drug release from all formulation was evaluated on the basis of zero order, first order, Hixon-Crowell, Higuchi equation and Peppas model. Based on different parameters i.e. folding endurance, drug content, moisture absorption, moisture loss, water vapor transmission rate in-vitro release study buccal patches of batch F4 (HPMC K4M and Eudragit RL 100) was found to an optimum formulation.
Authors and Affiliations
Okorochukwu Nnamdi, Ihuaku Emmanuel C.
Keywords
Related Articles
- EP ID EP36390
- DOI https://doi.org/10.22270/ujpr.v2i3.R2
- Views 299
- Downloads 0
TRACE METALS IN SURFACE SEAWATERS IN THE RED SEA AND GULF OF ADEN-YEMEN
The present work has been done considering the constant spread pollution of heavy metals in water bodies. Pollution among water bodies is a major global problem. This contaminates not only the water but also the sediment...
ESTIMATION OF ANTI-INFLAMMATORY ACTIVITY AS WELL AS APOPTOTIC ACTIVITY OF ETHANOLIC EXTRACTS OF CROCUS SATIVUS
Inflammation is a body reaction which embroils cellular and biochemical responses, which is not only symptom for shared diseases but also known to be an initial phase for certain serious Alzheimer’s, cancer, heart vascul...
RIBAVIRIN LOADED ERYTHROCYTES BY ENDOCYTOSIS AS TARGETED DRUG CARRIER SYSTEM
Loaded erythrocytes, as drug carrier system, has tremendous potential to carry outside specificity and sustained release of drug. Thereby, enhancing therapeutic index and minimize the dose and adverse effects as well as...
HOW DO VITAMIN AND PLANT SEEDS WORK AS HYPOLIPIDEMIC AGENTS ?
Cardiovascular diseases are leading cause of death in western and eastern countries of the world. Hyperlipidemia is one of the strong risk fractions for heart diseases. To evaluate hypolipidemic drugs efficacy, the study...
DEVELOPMENT AND CHARACTERIZATION OF DIRECT COMPRESSED MATRIX MINI TABLETS OF NAPROXEN SODIUM
The present study was carried out to formulate and evaluate multiparticulate system containing mini-tablets of Naproxen sodium. Naproxen is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic pr...