DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES FOR BUCCAL DELIVERY OF PREGABALIN
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 3
Abstract
Pregabalin is a structural analogue of the inhibitory neurotransmitter γ-amino butyric acid (GABA) having short half-life (5-6 hrs) and is used in the management of epilepsy. The aim of this study was to prepare a buccal patch containing Pregabalin by the means of solvent casting method. Six formulations were prepared using different ratio of polymers including HPMC K4M, Eudragit RL, and PVP K30. Since buccal mucosa is relatively permeable with rich blood supply and acts as an excellent site for the absorption of drugs so, it is an attractive alternate to other conventional methods of systemic drug administration. Franz diffusion cell with commercially available dialysis membrane was used for the in-vitro diffusion study of buccal patches for duration of 12 hrs. Kinetics and mechanism of drug release from all formulation was evaluated on the basis of zero order, first order, Hixon-Crowell, Higuchi equation and Peppas model. Based on different parameters i.e. folding endurance, drug content, moisture absorption, moisture loss, water vapor transmission rate in-vitro release study buccal patches of batch F4 (HPMC K4M and Eudragit RL 100) was found to an optimum formulation.
Authors and Affiliations
Okorochukwu Nnamdi, Ihuaku Emmanuel C.
Keywords
Related Articles
- EP ID EP36390
- DOI https://doi.org/10.22270/ujpr.v2i3.R2
- Views 328
- Downloads 0
COLON SPECIFIC DRUG DELIVERY SYSTEMS: CURRENT TRENDS AND APPROACHES
The colon is a site where both local and systemic delivery of drugs can take place. The colon targeted drug delivery system is used for the treatment of various diseases related to colon like Crohn’s disease, ulcerative...
THE IMPACT OF STRATEGIC FACTORS OF WASTE MANAGEMENT ON ENVIRONMENTAL PROTECTION IN KAZEROON CITY IN 2017
Today, environment protection is one of main pillars of observing human right, so that protection and maintenance of environment is one of main duties of present and future. After investigating and identifying environmen...
A REVIEW OF BREAST CANCER RISK FACTORS
Breast cancer is a commonly diagnosed neoplastic ailment in females particularly near menopause. This ailment signifies a substantial health problem as it has influenced a large number of women. Several risk factors are...
COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY
High lipid levels in blood circulation may interact with free radicals, formed in consequence of normal metabolic processes in human body. This interaction is one of the etiological factors for development of coronary ar...
FABRICATION AND CHARACTERIZATION OF EZETIMIBE SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT
The objective of the present study was to formulate solid dispersions (SD) of Ezetimibe to improve the solubility and dissolution rate to facilitate faster onset of action. Ezetimibe is a poorly water soluble BCS class I...