Development and charecterization of PLGA-nanoparticles containing cavedilol
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 3
Abstract
The objective of this study was to prepare PLGA nanoparticles of Carvedilol that will improve the bioavailability of Carvedilol and sustain the release to reduce the initial hypotensive peak and to prolong the antihypertensiveeffect of the drug. Carvedilol encapsulated by Nanoprecipitation method using PLGA and Pluronic F-68.Prepared nanoparticles were examined for physicochemical characteristics, in vitro release kinetics and invivobiodistribution studies. Average size of the nanoparticles were in range of 132-234nm. The drug encapsulation efficiency was 77.6% at 33% drug loading. In vitro cumulative release from the nanoparticles was 72% at 24hr.In vivo biodistribution studies in rats revealed that these particles are distributed in heart, liver and kidney at higher concentration may allow their delivery to target sites.
Authors and Affiliations
Jawahar N, Nagasamy Venkatesh D, Sureshkumar R, Senthil V, Ganesh G. N. K. , Vinoth P. , Sumeet Sood , Samanta M. K.
Keywords
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