DEVELOPMENT AND COMPARISON OF ORALLY INHALABLE SUSTAINED RELEASE FORMULATIONS FOR THREE RESPIRATORY DRUGS FOR ASTHMA
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2016, Vol 12, Issue 25
Abstract
The present work was designed to develop and compare orally inhalable sustained release formulation for salbutamol sulphate (SS), ambroxol hydrochloride (AH) and montelukast sodium (MS).The emulsion solvent evaporation method was used to prepare microparticles with the polymers. The prepared polymer encapsulated microparticles were blended with carrier inhalable lactose and filled in size 3 hard empty gelatin capsule. Formulations T1-T9 were prepared with 1:1 ratio of PLGA (50:50), PLGA (75:25) and Eudragit RS100. The formulation T1 prepared with SS:PLGA (50:50) produces best result when compared with other formulations T2-T9. Formulation T1 gives in vitro release 91.23% at 12 h and having particle size of microparticles (D0.5 µm) 1.94±0.6 and respiratory fraction 34.9± 2.59 %.
Authors and Affiliations
K. Sathish kumar, C. Kumaresan, R. Anantharaj
Keywords
Related Articles
- EP ID EP653052
- DOI 10.24297/jac.v12i25.4658
- Views 146
- Downloads 0
Optimisation of solar panel efficiency for Solar powered vehicle
The aim of the project is to increase the efficiency of the solar panel. Solar technology offers great potential in terms of supplying the world’s energy needs. The effective way of utilizing sunlight with solar energy...
The Present Status and Prospect of Research on Rapid Freeze-drying Food in China
The basic principles, process, features, technology advances, mechanistic modelling of the phenomena involved and present status of freeze-dried food were introduced in this paper, in which the main problems of the freez...
Molecular Simulation of Hyperbranched Polyester
A new types of hyperbranched polyester was synthesized by the 2,2-bis(hydroxymethyl) propionic acid as an AB2-type monomer and glycerol as the core moiety. Molecular weights were confirmed by Gel Permeation Chromatograph...
Synthesis, Spectral Characterization and Antimicrobial Studies of Co(II) Complexes with Tetradentate Schiff bases Derived from Ortho-Phthalaldehyde
A series of cobalt (II) complexes have been synthesized with Schiff bases derived from ortho-phthalaldehyde and various amines in aqueous methanol solution. The newly synthesized Schiff bases and their Co (II) complexes...
Synthesis and vibrational study of phosphate-sulfate fluorapatites Ca10-xNax(PO4)6-x(SO4)xF2 (0≤ x ≤6)
   A series of phosphate-sulfate fluorapatites Ca10-xNax(SO4)x(PO4)6-xF2 has been synthesized by the solid-state reaction at high temperature. The samples were characterized using X-ray diffraction, Infrared spectr...