Development and evaluation of Bosentan monohydrate loaded lipid-solid dispersions
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 5, Issue 6
Abstract
In the last decade of the last century, solid lipid dispersions (SLD) have been introduced to the literature as a novel carrier system for cosmetic active ingredients and pharmaceutical drugs. SLD consists of biodegradable physiological lipids or lipidic substances and stabilizers which are generally recognized as safe (GRAS) or have a regulatory accepted status. Compared to other delivery systems such as liposomes, microemulsions and polymeric nanoparticles, SLD possess various advantages. Examples are production without organic solvents, long time physical stability and the possibility of protection of chemically labile actives inside the particles. This chapter describes the composition, production procedures, characterization of quality and stability of SLN dispersions and describes possibilities for application of this colloidal carrier system.
Authors and Affiliations
R Sridhar Babu, Anil Kumar Middha, Kishore DV, Karunakranth D
Keywords
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