Abstract

Current investigation explains the preparation of alginate microspheres of Ropinirole by ionotropic gelation technique, we sought to develop novel Ropinirole microspheres and explore the influence of various concentrations of sodium alginate, Eudragit RS100, Gum Kondagogu and calcium chloride on particle size, entrapment efficiency, and drug release of the same. The prepared microspheres were found to be discrete, spherical with free-flowing properties and were evaluated with regarding percentage yield, entrapment efficiency followed by drug release and characterization was studied using FTIR, DSC, SEM analysis. Among the total S14 formulations, S13 formulation was selected as optimized preparation. The in vitro dissolution showed sustained release of Ropinirole up to 97.54±5.05% by diffusion mechanism over 12hrs which followed the zero order and Higuchi model (R2 = 0.9894,0.9771) respectively, and it followed Non Fickian diffusion. The marketed product displayed the drug release of 90.16±5.00 within 12 hr. From these results it was concluded that, the drug release from the optimized formulation was in controlled manner and completely within 12h. Key Words: Ropinirole, Parkinson’s disease, SEM, FTIR, Ionotropic gelation.

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