DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 3
Abstract
The aim of this study was to develop a novel gastro retentive oral floating in situ gelling system for controlled release of Meloxicam. Meloxicam is a NSAID that inhibits cyclooxygenase (COX) synthesis and has analgesic and antipyretic effects. Four polymer based floating in situ gelling systems of Meloxicam were prepared by dissolving varying concentrations of different ingredients including sodium alginate, HPMC K100M, calcium carbonate, sodium citrate. The prepared gels were characterized for solution viscosity, pH, gelling capacity, floating lag time, floating duration and in-vitro release study. All the formulations showed instant gelation maintaining integrity for at least 12 h. The study demonstrated that a stomach specific in-situ gel of Meloxicam could be prepared using the floating mechanism to increase the residence time of the drug in the stomach and improve bioavailability and thus improve patient compliance.
Authors and Affiliations
Anyanwu NC J, Adogo L Y, Ajide B
Keywords
Related Articles
- EP ID EP36391
- DOI https://doi.org/10.22270/ujpr.v2i3.R3
- Views 313
- Downloads 0
DESIGN AND EVALUATION OF CARBAMAZEPINE LOZENGES
Lozenges are the flavoured solid, unit dosage medicated dosage forms usually in the sweetened base intended to be sucked and held in the mouth or pharynx containing one or more medicaments. Lozenges were developed in 20...
ANTIHYPERGLYCEMIC AND ANTI-OXIDANT POTENTIAL OF ETHANOL EXTRACT OF VITEX THYRSIFLORA LEAVES ON DIABETIC RATS
The antihyperglycemic effect of an ethanol extract of Vitex thyrsiflora leaves was investigated in normal male rats and streptozotocin‐induced diabetic male rats and its antioxidant potential was evaluated. After prepara...
PREVALENCE OF HBV AND HCV; AND THEIR ASSOCIATED RISK FACTORS AMONG PUBLIC HEALTH CENTER CLEANERS AT SELECTED PUBLIC HEALTH CENTERS IN SANA'A CITY-YEMEN
Occupational exposure of public health center cleaners (PHCCs) to blood and body fluids after skin injury or mucous membrane contact constitutes a risk for transmission of blood-borne pathogens. In the industrialized wor...
A COMPREHENSIVE REVIEW ON SUSTAINED RELEASE MATRIX TABLETS: A PROMISING DOSAGE FORM
Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, least aseptic and flexibility in the design of dosage form. The objective of the study was to explore the...
WOUND DRESSINGS UPLOADED WITH MYRTLE BERRIES EXTRACT AND NIGELLA SATIVA HONEY
Wound dressings are frequently developed by introducing new products to target different aspects of the wound healing process. Many medicated dressings incorporated with natural extracts and chemicals have been developed...