DEVELOPMENT AND EVALUATION OF KETOROLAC TROMETHAMINE MUCOADHESIVE BUCCAL TABLETS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: The aim of the present study was to develop and evaluate buccal mucoadhesive tablets of ketorolac tromethamine.Methods: The tablets were prepared by direct compression using bioadhesive polymers such as carbobpl 934 with hydroxylpropyl methylcellulose K4M and sodium carboxymethyl cellulose. The prepared tablets were characterized by different parameters such as weight uniformity, content uniformity, hardness, swelling index, in vitro drug release studies, ex- vivo residence time and ex- vivo permeation study.Results: F7 formulation containing Carbopol 934 and SCMC (at the ratio 1:3, respectively) showed good swelling, a convenient residence time as well as the highest amount of drug released within 6 hrs. Stability studies in natural saliva for 6 hrs, indicated that optimized F7 formulation has good stability in human saliva. In addition to the good correlation obtained between in vitro drug release and ex-vivo drug permeation study. Conclusion: The buccal mucoadhesive tablet of ketorolac could be an alternative route to reduce the pronounced gastrointestinal irritations, reduce dosing frequency to improve patient complains.
Authors and Affiliations
Marwa Shukr, Amal Abdel Rahim
Keywords
Related Articles
- EP ID EP579710
- DOI -
- Views 138
- Downloads 0
COMPUTER-AIDED MODEL FOR BREAST CANCER DETECTION IN MAMMOGRAMS
The objective of this research was to introduce a new system for automated detection of breast masses in mammography images. The system will be able to discriminate if the image has a mass or not, as well as benign and m...
THE EFFECT OF VANCOMYCIN DOSES GREATER THAN 2 GRAMS ON SERUM CREATININE AND VANCOMYCIN TROUGH LEVELS
Objective: To assess the effect of vancomycin doses greater than 2 grams on renal function and vancomycin trough levelsMethods: This is a retrospective, pharmacokinetic study performed in a tertiary care level II trauma...
ANTIDIABETIC ACTIVITY OF ASYSTASIA GANGETICA (L.) T. ANDERSON FLOWER EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Objective: Asystasia gangetica has long been used in the antiasthmatic medicinal preparations of traditional healers Nigeria of South Africa, in India the plant is being used for treating diabetes and microbial infection...
FAST CHIRAL HPLC PROCEDURE FOR THE SIMULTANEOUS DETERMINATION OF DROPROPIZINE ENANTIOMERS AND ITS NONPOLAR IMPURITY IN RAW MATERIAL AND PHARMACEUTICAL FORMULATION
Objective: Levodropropizine is a novel antitussive drug, which occurs as enantiomers. They are levodropropizine (2S) [LDP] and dextrodropropizine (impurity A) (2R) [DDP]. An isocratic chiral high performance liquid chrom...
BIOLOGICAL ACTIVITIES OF EXTRACTS FROM PADINA BOERGESENII AND SARGASSUM STENOPHYLLUM, SEAWEEDS NATURALLY FOUND IN BAIA DE TODOS OS SANTOS, BRAZIL
Objective: Here we present the results of the biological potential as antioxidant, anti-cancer and leishmaniscidal from extracts of Padina boergesenii Allender & Kraft and of Sargassum stenophyllum Martius, seaweed s...