Abstract

The aim of the present study was to develop site specific drug delivery of ornidazole for the treatment of periodontitis which has excellent activity against anaerobic microorganisms. The formulations were prepared by utilizing polymers such as PEO and gellan gum by solvent technique with the used of plasticizer (PEG-400). The calibration curve of ornidazole was developed in PBS pH 6.8 at 317nm in the range of 2 to 20 µg/ml. Compatibility study were carried out by FT-IR and Differential scanning Colorimetry. The formulations were evaluated for thickness, folding endurance, weight variation, drug content, percent moisture loss, tensile strength, and percent elongation, SEM and in vitro antibacterial activity. In vitro drug release study was also carried out using PBS pH 6.8 and the samples were analyzed by UV-spectrophotometrically at 317nm. FT-IR and DSC study revealed no interaction between drug and polymers. Formulations shown good uniformity of drug content, there is no any kind of effect on moisture loss test. Formulations showed thickness within the range of 0.0417 to 0.0633. Formulations F3, F4, F7 and F8 showed good tensile strength. By increasing the concentration of PEO in the formulation increases the tensile strength, percent elongation and folding endurance. Formulation F3 released 92.44% of drug at the end of three minute and was considered as best formulation. A short-term stability study of the optimized formulation F3 was carried out at 400C for three months. At periodic interval sample were analyzed for drug content and in vitro drug release study, result showed 91.66% release at the end of 90days. Keywords: Ornidazole, dental strip, Physical characterization, in vitro release, antibacterial study

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