Development and evaluation of some novel polyherbal anti-inflammatory and analgesic formulations of some Indian spices
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2017, Vol 5, Issue 3
Abstract
Inflammation is linked with a broad range of infectious and non-infectious diseases; hence, also considered on root of the all diseases. The crucial role of inflammatory processes makes possible evaluation research focusing on the treatment of inflammation. Aim: The present study was aimed to develop and evaluate some novel polyherbal anti-inflammatory and analgesic formulations of some Indian spices. Materials and Methods: Rhizome of Zingiber officinale. C. longa, bulb of A. sativum, and fruit of C. annuum were collected locally. Animals were procured from the institute and the protocol adhered to the IAEC guidelines. Herbal drugs were extracted using soxhelet apparatus. gel, cream, and ointment formulations were prepared using different concentrations of the herbal compounds. The formulations were then physically evaluated for pH, viscosity, spreadability, and stability. Acute toxicity studies were also performed in the animals. Anti-inflammatory activity was evaluated using paw edema method, cotton-pellet-induced granuloma method, and ultraviolet erythema induction. Tail flick, hot plate, and tail immersion methods were used for evaluation of analgesic activity. Diclofenac sodium was used as standard drug. Data were presented as mean ± standard deviation wherever applicable. For continuous variables, Student’s t-test was used to differentiate mean difference. For comparison between more than 2 groups, one-way analysis of variance was used followed by post hoc analysis. P < 0.05 was considered significant. Statistical analysis was performed using SPSS trial version 21. Results: In acute toxicity studies, the animals could tolerate a dose >2000 mg/kg body weight with no mortality. Our study results showed that gel, cream, and ointment formulations in all polyherbal combinations significantly inhibited paw edema, cotton pellet-induced granuloma, and formation of erythrema. However, the activities were highest for gel formulation. These results supported that the polyherbal formulations significantly exhibit anti-inflammatory and analgesic activities. Conclusion: Gel formulations among prepared topical formulations showed the highest activity and also exhibited nonstaining, good spreadability, and patient compliance. Topical formulations containing spices can be used in chronic inflammatory and pain conditions and devoid of side effects.
Authors and Affiliations
Sachin Jadhav
Keywords
Related Articles
- EP ID EP570238
- DOI -
- Views 60
- Downloads 0
Antioxidant study on Cucurbita maxima fam Cucurbitaceae
In any biochemical process there is biotransformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaki...
Pleiotropic actions of PPAR agonist: A potential therapeutic perspectives in the treatment of diabetic nephropathy
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARα activators reduce the quantities of available...
Antidepressant activity of “Cissampelos pareria” extract in mice
Depression is a wide spread psychiatric disorder affecting around 5% of the population and it is difficult to predict the patient response to any given treatment. The present study aimed at studying the pharmacological a...
In vitro comparative studies of antioxidant action of different parts of sweet and bitter variety of Lagenaria siceraria
Objective: The object of the present investigation is to verify the antioxidant activity of sweet and bitter variety of Lagenaria siceraria (LS) and to investigate the medicinal properties of whole plants. Materials: Asc...
Profile picture of risk factors for breast cancer among community women of Udupi, Karnataka
Globally, breast cancer is considered to be one amongst the most commonly cancer. In India, it is considered to be the second cancer disease among women with most of the affected population is in the urban areas. Accordi...