DEVELOPMENT AND EVALUATION OF SUBLINGUAL TABLET OF ZOLPIDEM TARTRATE AN ANTIPSYCHOTIC DRUG
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
Objective: The present work aims to develop and evaluate sublingual tablets of Zolpidem Tartrate used for the short-term treatment of insomnia.Methods: The tablet of Zolpidem Tartrate was prepared by direct compression technique using two classes of super disintegrates represented by Crospovidone and Sodium Starch Glycolate (SSG) and the efficiency of these super disintegrants in the tablets was compared with various tests like disintegration time, waiting time, water absorption ratio, in-vitro dissolution profile and stability study.Results: The disintegration efficiency of Crospovidone is better than SSG. Fourier Transform Infrared (FT-IR) spectrum of pure drug and the mixture of drug polymers revealed no chemical interaction. The pre-compression study indicated good flow properties of the bulk powder. In-vitro drug release from the formulations was studied using buffer pH 6.8. From the entire formulations, F5 and F6 containing 4 % and 5 % of Crospovidone conceded as an optimized formulation which is showing the drug release of 102.00±0.21 % and 103.10±0.42 % in 30 min considerably.Conclusion: The results indicated that delivery of Zolpidem Tartrate into the systemic circulation via the sublingual route to improving its bio-availability and circumvent the first-pass effect. The optimized formulations were also found to be stable during stability studies conducted for 3 mg as per ICH guidelines.Keywords: Insomnia, Zolpidem Tartrate, Crospovidone, Sodium Starch Glycolate, In-vitro disintegration, In-vitrodrug release, Sublingual tabletÂ
Authors and Affiliations
Manjula Talluri, Shakti Saha, Sachin Basavaraj Adahalli
Keywords
Related Articles
- EP ID EP577790
- DOI -
- Views 61
- Downloads 0
ANTIMYCOBACTERIAL, ANTIMICROBIAL AND ANTIFUNGAL ACTIVITIES OF GERANIUM OIL-LOADED NANO CAPSULES
Objective: The aim of this study was to perform the first ever investigation of the effect of activities in the nano capsules containing Geranium oil (NC1) against different species of pathogens such as Mycobacterium...
EXPERIMENTAL AND COMPUTATIONAL STUDY OF BINDING INTERACTION OF ALKOXY DERIVATIVES OF N-ARYLHYDROXAMIC ACIDS WITH DNA
Objective: Â Binding affinity towards DNA for small molecules is very important in the development of new therapeutic reagents. Interaction between N-Arylhydroxamic acid derivatives N-p-Tolyl-4-Ethoxybenzohydroxamic acid...
EXPRESSION AND ENZYMATIC PROPERTIES OF A UNIQUE RECOMBINANT ANTICOAGULANT AND FIBRINOLYTIC ENZYME FROM ACINETOBACTER BAUMANNII TU04
Objective: The objective of this research is to clone and express a new fibrinolytic enzyme encoding serine protease gene in Escherichia coli thus, characterize such purified recombinant.Methods: The recombinant clone wa...
EFFECT OF HEAT AND FILTER STERILIZATION ON THE EFFICIENCY OF COLEUS AROMATICUS AS AN ANTIBACTERIAL AGENT AGAINST DIABETIC WOUND PATHOGENS
Objective: The purpose of the present study is to evaluate the effect of sterilization on the efficiency of Coleus aromaticus on eradicating diabetic wound pathogens. Methods: The investigation was explored by deploying...
ANTIEPILEPTIC ACTIVITY OF SOME NOVEL SUBSTITUTED FLUORO BENZOTHIAZOLE DERIVATIVES
Objective: The aim of the study is to investigate and to reveal the antiepileptic activity of fluoro substituted benzothiazole derivatives (FBTDs) in experimental induced epilepsy in mice.Methods: The acute oral toxicity...