DEVELOPMENT AND EVALUATION OF TOPICAL LIPOSOMAL GEL LOADED WITH TAZAROTENE IN COMBINATION WITH HYDROQUINONE
Journal Title: Asian Journal of Pharmaceutical Education and Research - Year 2018, Vol 7, Issue 2
Abstract
The aim of the present study was to statistically optimize the vesicular formulations (Liposomes) for enhanced skin delivery of a model drug tazarotene in combination with gel contains hydroquinone. Regular 23 factorial designs were employed for screening of significant formulation and process variables involved in the development of liposome. The optimization batches (TL1 toTL8) were prepared by lipid film hydration method with different concentration of lecithin and cholestrol with different varying stirring speed (100 and 200 rpm) All the prepared formulation were characterized for vesicle morphology, particle size and entrapment efficiency by transmission electron microscopy (TEM). The optimized batch of tazarotene liposome TL6 was further incorporated into gel containing hydroquinone. Three different formulation (LF1, LF2, LF3) were prepared using different composition of carbopol (0.5, 1.0 and 2%) The optimized batch of tazarotene and hydroquinone incorporated gel (1%) was characterized for pH, spreadability, viscosity (cps) and in vitro drug release. The percentage drug entrapment efficiency found higher in formulation TL6, Vesicular size and drug entrapment efficiency of the optimized liposomes were found to be 180.4 nm and 69.10% respectively. In-vitro diffusion study demonstrated that the drug diffused from liposomal gel and conventional marketed gel was found to be 98.12% and 98.58% respectively. It can be concluded from the experimental results that the liposomal gel containing tazarotene in combination with hydroquinone has potential application in topical delivery.
Authors and Affiliations
A. Bhardwaj, M. L. Kori
Keywords
Related Articles
- EP ID EP402239
- DOI -
- Views 127
- Downloads 0
ANTI-ANEMIC ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF BRASSICA OLERACEA VAR IN PHENYLHYDRAZINE INDUCED ANEMIC RATS
The study deals with the evaluation of anti-anemic activity of oral administration of hydro-alcoholic extract of fruit of Brassica oleracea at different dosage levels (250 & 500mg/kg body weight) on female Wistar rats us...
AN OVERVIEW OF CONGESTIVE HEART FAILURE AND ITS NOVEL TREATMENT APPROACHES
Congestive heart failure (CHF) is a common clinical disorder that results in pulmonary vascular congestion with reduced cardiac output and describes the inability of the heart to meet the needs of organs and tissues for...
ACENOCOUMAROL (NICOUMALONE) INDUCED GASTROINTESTINAL BLEEDING
Nicoumalone is an oral vitamin K antagonist prescribed for the prevention and treatment of venous thromboembolism. The major challenge faced during the therapy were control of bleeding and identification of risk factor w...
ANTI-DIABETIC ACTIVITY OF SILVER NANOPARTICLES SYNTHESIZED FROM ASHWAGANDHA ROOT AQUEOUS EXTRACT
According to traditional medicine, Withania somnifera also known as Indian ginseng is a plant with a cure for many diseases. This study was conducted to develop an ecofriendly, cheap and effective procedure for the green...
A COMPARATIVE STUDY ON ANTIMICROBIAL ACTIVITY OF ROOT EXTRACT OF GLYCYRRHIZA GLABRA AND LEAVES EXTRACT OF ASPARAGUS RACEMOSUS
This study was carried out to evaluate the antimicrobial activity of Hydroalcoholic extract (80% ethanol) of Glycyrrhiza glabra root and Asparagus Racemosus leaves. The antimicrobial activity was determined by the well d...