DEVELOPMENT AND IN VITRO EVALUATION OF BUCCOADHESIVE TABLETS OF LOSARTAN POTASSIUM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
Buccoadhesion, or the attachment of a natural or synthetic polymer to a biological substrate, is a practical method of drug immobilization or localization and an important new aspect of controlled drug delivery. The unique environment of the oral (buccal) cavity offers its potential as a site for drug delivery. Because of the rich blood supply and direct access to systemic circulation. The Buccal route is suitable for drugs, which are susceptible to acid hydrolysis in the stomach or which are extensively metabolized in the liver (first pass effect). Oral controlled release (CR) systems continue to be most popular once amongst all the drug delivery systems. Mucoadhesive delivery systems offer several advantages over other oral CR systems by virtue of prolongation of residence time of drug in buccal mucosa, and targeting and localization of the dosage form at a specific site. Also, these mucoadhesive systems are known to provide intimate contact between dosage form and the absorptive mucosa, resulting thereby in high drug flux through the absorptive tissue. Losartan potassium is an angiotensin II receptor (type AT1) antagonist. Administration of conventional tablets of Losartan potassium has been reported to exhibit fluctuations in the plasma drug levels, resulting either in manifestation of side effects or reduction in drug concentration at the receptor site. Losartan Potassium is having less bioavailability (25-35%). In order to increase the bioavailability to avoid the hepatic metabolism, the buccal tablets of Losartan potassium were prepared.
Authors and Affiliations
Achanta Raviteja , S. Chandra, K. G. Parthiban, Naveen Kante, Sandeep Devareddy
Keywords
Related Articles
- EP ID EP125055
- DOI -
- Views 104
- Downloads 0
A COMPREHENSIVE REVIEW ON GISEKIA PHARNACEOIDES LINN. (MOLLUGINACEAE)
Natural products are the source of drug leads from time immemorial. Therapeutically interesting and important drugs has been developed from plant source which are being used in traditional system of medicine. One such pl...
LABORATORY MODELS FOR SCREENING ANALGESICS
Pain is a complex unpleasant phenomenon composed of sensory experiences that include time, space, intensity, emotion, cognition and motivation. Analgesics are the agents, which selectively relieve pain by acting in the C...
ENHANCING SOLUBILITY AND DISSOLUTION OF MEFENAMIC ACID BY FREEZE DRYING USING β-CYCLODEXTRIN
Mefenamic acid, an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of Mefenamic acid by prepa...
DEMOGRAPHIC AND CLINICAL ASPECTS OF TUBERCULOSIS: A CASE SERIES OF PATIENTS FROM IN-PATIENT DEPARTMENT OF A HOSPITAL
Controlling tuberculosis in India is a tremendous challenge. The disease is a major barrier to social and economic development. Based on the current scenario, the present observational prospective study was designed for...
EAT TIL AND PROTECT DIL
Sesame seeds have been grown in tropical regions throughout the world since pre-historic times. Sesame seeds look like tiny and simple pieces of nature. Sesame seeds seem to have originated in the Indian subcontinent. T...