DEVELOPMENT AND IN-VITRO EVALUATION OF MATRIX-TYPE TRANSDERMAL PATCHES OF LOSARTAN POTASSIUM
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 2
Abstract
Since last decade drugs through skin has received great attention of many researchers. The aim of present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan potassium using blends of different polymeric combinations of polyvinylpyrrolidone K30 (PVP K30) and ethylcellulose (EC), hydroxypropyl methyl cellulose and chitosan. Physical studies including thickness, folding endurance moisture content, tensile strength and flatness were performed on all formulations. In-vitro diffusion study of 10 hrs was performed by means of Franz diffusion cell. All the formulations were found to be suitable for formulating in terms of physicochemical characteristics. Stability study performed on selective batch, TP1 for 12 weeks at different temperature indicates stability of transdermal patches at room temperature. Present study concluded that Losartan potassium can be formulated into the transdermal matrix type patches to sustain its release characteristics. Polymeric composition of batch TP1 (PVP K30 : Chitosan:: 70:30) was found to be the best choice for manufacturing transdermal patches of Losartan potassium among the formulations studied.
Authors and Affiliations
Fatima A . Adamude, Uhama Kingsley Chukwuka
Keywords
Related Articles
- EP ID EP36385
- DOI https://doi.org/10.22270/ujpr.v2i2.R5
- Views 331
- Downloads 0
VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW
Vitamin A and its derivative retinoic acid (13-cis RA, 9-cis RA, all-trans RA) and recent tamibarotene have been shown a broad variety of biological actives in human, such as vision, embryonic development, cell growth an...
ANTIMICROBIAL ACTIVITIES FOR HADHRAMI HONEY ON GROWTH OF SOME PATHOGENIC BACTERIA
The majority of the Yemeni honey varieties are characterized by low moisture content, in addition to the various flora of Yemeni plant, which may not be found in many countries, which makes them of high medicinal importa...
TABLET GRANULATION: CURRENT SCENARIO AND RECENT ADVANCES
Granulation is a size enlargement process, in fine or coarse particles converted into physically stronger and larger agglomerates having good flow property, better compression characteristics and uniformity, prevent segr...
COMPARATIVE ANALYSIS OF THE PHYTOCHEMICAL COMPOSITIONS OF LEAF, STEM-BARK AND ROOT OF AZADIRACHTA INDICA (NEEM)
Plant chemicals abound in different parts of plants, in different compositions. Thus, the comparative screening of the leaf, stem-bark and root of Azadirachta Indica becomes imperative. The presence of nine phytochemical...
FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION
The Fast Dissolving Drug Delivery Systems sets a new benchmark was an expansion that came into existence in the early 1980’s and combat over the use of the different dosage form like tablets, suspension, syrups, capsules...