DEVELOPMENT AND IN-VITRO EVALUATION OF MATRIX-TYPE TRANSDERMAL PATCHES OF LOSARTAN POTASSIUM
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 2
Abstract
Since last decade drugs through skin has received great attention of many researchers. The aim of present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan potassium using blends of different polymeric combinations of polyvinylpyrrolidone K30 (PVP K30) and ethylcellulose (EC), hydroxypropyl methyl cellulose and chitosan. Physical studies including thickness, folding endurance moisture content, tensile strength and flatness were performed on all formulations. In-vitro diffusion study of 10 hrs was performed by means of Franz diffusion cell. All the formulations were found to be suitable for formulating in terms of physicochemical characteristics. Stability study performed on selective batch, TP1 for 12 weeks at different temperature indicates stability of transdermal patches at room temperature. Present study concluded that Losartan potassium can be formulated into the transdermal matrix type patches to sustain its release characteristics. Polymeric composition of batch TP1 (PVP K30 : Chitosan:: 70:30) was found to be the best choice for manufacturing transdermal patches of Losartan potassium among the formulations studied.
Authors and Affiliations
Fatima A . Adamude, Uhama Kingsley Chukwuka
Keywords
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- EP ID EP36385
- DOI https://doi.org/10.22270/ujpr.v2i2.R5
- Views 295
- Downloads 0
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