DEVELOPMENT AND OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 5
Abstract
Objective:To optimize and develop Bi layered floating tablet (SFMS) containing ulcer protective Sucralfate as immediate release layer and anti hypertensiveMetoprolol Succinate as sustained release layer. Method: 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate is taken. By changing the concentration of Superdisintigrant, Surfectants, Alkalizing agents & Binding agents of Sucralfate and changing concentrations of Alkalizing agents and Polymers of Metoprolol Succinate the OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) is generated.. Result: Within 5 minutes in acidic medium , 7% Superdisintigant (Crosspovidone), 7% Surfectant (Polysorbate-80), 15% Alkalizing agents(Sodium bicarbonate), 5% HPC (Binding agent) averagely produce 68.56%drug release. Within 20 hours in acidic medium , 30% Alkalizing agents(Sodium bicarbonate) , 50% Soluablepolymer (HPMC K) ,40% Polymer (Udragid RSPO, 35% HPC Polymer(NaCMC), 30% Polymer (Sodiumalginate) ,25% Polymer (HPC) , 20% Polymer, Udragid RS), 5% HPC Polymer (PVPK) produce averagely100.06% drug release. Conclusion:The optimized formulation 400 mg tablet weight of OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) produce better result and identified as better formulation for further studies.
Authors and Affiliations
Sreedhar Ranjan Das , Bibhuti Bhusan Panigrahi And Manoj Kumar Pani.
Keywords
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- EP ID EP601086
- DOI 10.21474/IJAR01/9105
- Views 79
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