Development and validation of a new stability indicating liquid chromatographic method for the simultaneous determination of thiocholchicoside and etoricoxib in combined dosage form
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 1
Abstract
A simple and sensitive stability indicating RP-HPLC method was developed and validated for the simultaneous determination of thiocholchicoside and etoricoxib in combined dosage forms. The separation of thiocholchicoside and etoricoxib was performed with the use of Hypersil BDS C18 column (250×4.6 mm;5μm particle size) and a mobile phase consisting of phosphate buffer(pH-3.4) and acetonitrile in the ratio of 35:65 v/v at a flow rate of 1.0 mL/min with UV detection at 260nm. The retention times of thiocholchicoside and etoricoxib were found to be 2.83 and 6.92min respectively. The obtained validation results and statistical parameters for thiocholchicoside and etoricoxib in formulations were satisfactory and were according to ICH guidelines.
Authors and Affiliations
Padmavathi k
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