DEVELOPMENT AND VALIDATION OF A SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF ATORVASTATIN IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS)
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 4
Abstract
A simple, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS) has been developed and validated. The chromatographic system consisted of a LC-20 AT pump, SPD-20 A UV/visible detector. The separation was achieved from C18 column at 300C with a mobile phase consisting of 0.025 M phosphoric acid solution: acetonitrile (60:40 v/v, pH 3.0 adjusted with 80% phosphoric acid) at a flow rate of 1.2 ml/min and the retention time was 2.737± 0.019 min. The method was found selective and able to resolve drug peaks from formulation excipients. The calibration curve was linear over the concentration range of 2-20 μg/ml (r2 = 0.999). The proposed method was accurate with 100.14 ± 0.57% recovery and precise (%RSD of Intraday variation were 0.55% and 0.58% for Inter day variation). The method has been used to determine potency of prepared SEDDS. Potency in all the cases was found within 99.02%- 100.02%. Therefore, this method can be used as a more convenient and efficient option for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS).
Authors and Affiliations
Prof. Dr. SM Ashraful Islam
Keywords
Related Articles
- EP ID EP667344
- DOI -
- Views 114
- Downloads 0
AN OVERVIEW OF POLYAMIDOAMINE DENDRIMERS: STRUCTURE, PHYSICAL PROPERTIES, AND BIOMEDICAL APPLICATIONS
Polyamidoamine (PAMAM) dendrimers are the primary complete dendrimer family to be orchestrated, described and marketed. Dendrimers are hyper branched, monodispersed macromolecules with multivalent useful end bunches. Den...
ANTIMICROBIAL ACTIVITY OF ARTOCARPUS ALTILIS, (BREADFRUIT), AVERRHOA BILIMBI (SOURIE) AND CORDIA CURASSAVICA (BLACKSTAGE) STEM EXTRACT AGAINST STREPTOCOCCOUS MUTANS, IN PURSUIT OF NATURAL ANTICARIES AGENTS
The antibacterial activity of three plant extracts: Artocarpus altilis fruit and leaves (Breadfruit), Averrhoa bilimbi (Sourie) fruit and leaves and Cordia Curassavica (Blackstage) stem and leaf extracts were evaluated a...
IMPLEMENTATION OF A COMMUNITY PILOT CARDIOVASCULAR HEALTH PROGRAM
Mexico is currently suffering from serious problems of obesity based on data from the national survey of health - ENSANUT – 2016[1], shows that 70% of adults aged 30-60 suffer from overweight or obesity, seven in 10 adul...
EMERGING MULTIPLE DRUG STRUGGLING BACTERIAL SPECIES: DELIVERY CONDITIONS INSIDE HUMAN’S BODY
Multidrug-resistant organisms (MDROs), including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and certain gram-negative bacilli (GNB) have important infection control implica...
DIABETIC FOOT ULCER: A REVIEW
Diabetic foot problems are common throughout the world, resulting in major medical, social and economic consequences for the patients, their families and society. Foot ulcers affect 15% of diabetic patients during their...