DEVELOPMENT AND VALIDATION OF DIFFERENTIAL PULSE ANODIC STRIPPING VOLTAMMETRIC ANALYSIS OF SELENIUM (IV) IN BULK AND IN DOSAGE FORMULATIONS AT A GOLD ELECTRODE MULTI-MODIFIED WITH A MIXTURE OF 3, 3′-DIAMINOBENZIDINE.4HCL AND VITAMIN E
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 7
Abstract
Objective: A simple, direct and very sensitive differential pulse anodic stripping voltammetric analysis (DPASVA) of selenium (IV) in bulk and in dosage formulations using a gold electrode multi-modified with a mixture of 3,3′-diaminobenzidine.4HCl (Dab) and vitamin E (VE)-Nafion (AuEMDabVEN) has been studied.Methods: The method involves the study of various parameters (electrolyte, deposition time, pulse duration, pulse amplitude, etc.) affecting the Se(IV) determination. The proposed method was validated for specificity, linearity, precision and accuracy, repeatability, sensitivity (LOD and LOQ), robustness and solution stability with an average recovery of 98.1-100.32%.Results: Se(IV)was determined in an aqueous HClO4 (0.2M) medium of pH 0.22 at an accumulation potential of-250 mV and an accumulation time of 200 s for CSe(IV) at 1x10-8 to 1x10-6 mol/l (0.7896-78.96 ng/ml) and 350 s for CSe(IV) at 1x10-9 to 1x10-8 mol/l (0.07896-0.7896 ng/ml) with relative standard deviations (RSD)2.4% and 4.8%, respectively.Conclusion: This method showed very sensitive results for the determination of Se(IV) using an AuEMDabVEN than that obtained using the individual Dab or VE. This method could be applicable for the quantitative determination of the bulk Se(IV) as well as dosage formulations.
Authors and Affiliations
Abdul Azizs Ramadan, Hasna Mandil, Abdulrahman Shikh-debes
Keywords
Related Articles
- EP ID EP575599
- DOI 10.22159/ijpps.2017v9i7.18568
- Views 60
- Downloads 0
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