Development and validation of new colorimetric method for the estimation of Gatifloxacin & Dapoxentine HCl
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2015, Vol 5, Issue 2
Abstract
Colorimetric methods have been developed for the estimation of Gatifloxacin & Dapoxentine. Here Methods were based on reaction involving the formation of orange & black colored complex with Ferric Chloride in the presence of Acidic medium for Gatifloxacin & Dapoxentine respectively. The maximum absorbance of the solution was measured at 471nm& 541 nm against blank respectively. The calibration curve calculated obeys Beer’s law over the concentration range of 6-30& 20-40µg/ml. The method was validated based on ICH guidelines. The high recovery and low relative standard deviation confirms the suitability of the method for determination Gatifloxacin & Dapoxentine. Hence it is useful for the routine analysis of Gatifloxacin & Dapoxentine.
Authors and Affiliations
Raval Kashyap , U. Srinivasa
Keywords
Related Articles
- EP ID EP96409
- DOI -
- Views 117
- Downloads 0
Protein –protein docking studies on diabetes mellitus using insilico methods
Concurrent with the spread of the western lifestyle, the prevalence of all types of diabetes is on the rise in the world's population. The number of diabetics is increasing by 4-5% per year. It was long believed that the...
A Focus on E-Waste: Effects on Environment and Human Health
Electronic wastes can cause widespread environmental damage due to the use of toxic materials in the manufacture of electronic goods. Hazardous materials such as lead, mercury and hexavalent chromium in one form or the o...
Phytochemical screening and in vitro antimicrobial activity of various extracts of Phyllanthus amaraus
Medicinal plants play a key role in the human health care. Phyllanthus amaraus is an economical plant and posess Anti-microbial activity. About 80% of the world Population relies on the use of traditional medicine which...
Evaluation of In Vitro Antioxidant Activity of 1,2,3,4 -Tetrahydroquinazoline Derivatives
Quinazolines show a number of biological activities. The molecular manipulation of promising lead compound is still a major line of approach for the discovery of new drugs. Combination of two or more moieties into...
A review on method development and validation By using HPLC
High performance liquid chromatography (HPLC) is an analytical technique which is proficient to separate, detect and quantify various drugs and its related degradants. It is also employed to separate manufactured drugs f...