DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF ZALTOPROFEN IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 1
Abstract
A new RP-HPLC method was developed and validated for determination of Zaltoprofen in bulk and tablet dosage form. The estimation was carried out on Enable C18G (250 mm ×4.6 mm, 5 μm) column using Acetonitrile and Water in the ratio of 95:5 (v/v) as mobile phase. The flow rate was 1.0 ml/min and the effluent was monitored by UV detector at 331 nm. The retention time was 3.653 min and linearity was observed in the concentration range of 10-50 μg/ml. The percentage recovery was in good agreement with the labelled amount in the pharmaceutical formulation and the method was simple, precise and accurate for the determination of Zaltoprofen in bulk and pharmaceutical formulation.
Authors and Affiliations
Purnima Gandi*| Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institue of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530 049, Dr. Y. Srinivasa Rao| Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institue of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530 049, K. Vara Prasada Rao| Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institue of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530 049, T. Hemanth Kumar| Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institue of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530 049
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